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News and Views
Nature Immunology  5, 1206 - 1208 (2004)
doi:10.1038/ni1204-1206

Are dendritic cells afraid of commitment?

Anne O'Garra1 & Giorgio Trinchieri2

1  Anne O'Garra is with the Division of Immunoregulation, The National Institute for Medical Research, Mill Hill, NW7 1AA London, United Kingdom. aogarra@nimr.mrc.ac.uk

2  Giorgio Trinchieri is with the Laboratory for Immunological Research, Schering-Plough Research Institute, 69571 Dardilly, France. giorgio.trinchieri@yahoo.com

Dendritic cell subsets are thought to become committed to the dendritic cell lineage once they have differentiated from lymphoid or myeloid lineage precursors. However, this tenet has been challenged by data showing plasticity among the different subsets.

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