Four commissioned reviews describe recent discoveries on the cellular enzymatic machinery underlying peptide generation and presentation to lymphocytes. This focus is available free to registrants during the month of July.
Focus on Making Peptides for Presentation Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPIIpp661 - 669 Peter M Kloetzel Published online: 28 June 2004|doi:10.1038/ni1090 Abstract|Full text|PDF
(1,345K)
Focus on Making Peptides for Presentation Post-proteasomal antigen processing for major histocompatibility complex class I presentationpp670 - 677 Kenneth L Rock, Ian A York
& Alfred L Goldberg Published online: 28 June 2004|doi:10.1038/ni1089 Abstract|Full text|PDF
(170K)
Focus on Making Peptides for Presentation Cellular mechanisms governing cross-presentation of exogenous antigenspp678 - 684 Anne L Ackerman
& Peter Cresswell Published online: 28 June 2004|doi:10.1038/ni1082 Abstract|Full text|PDF
(569K)
Focus on Making Peptides for Presentation The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 moleculespp685 - 692 Colin Watts Published online: 28 June 2004|doi:10.1038/ni1088 Abstract|Full text|PDF
(237K)
Drug development strategies for asthma: in search of a new paradigmpp695 - 698 Patrick G Holt, Peter D Sly, Fernando D Martinez, Scott T Weiss, Bengt Björkstén, Erika von Mutius
& Ulrich Wahn doi:10.1038/ni0704-695 Abstract|Full text|PDF
(100K)
Separate domains of AID are required for somatic hypermutation and class-switch recombinationpp707 - 712 Reiko Shinkura, Satomi Ito, Nasim A Begum, Hitoshi Nagaoka, Masamichi Muramatsu, Kazuo Kinoshita, Yoshimasa Sakakibara, Hiroko Hijikata
& Tasuku Honjo Published online: 13 June 2004|doi:10.1038/ni1086 Abstract|Full text|PDF
(1,142K)
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zonepp713 - 720 Guy Cinamon, Mehrdad Matloubian, Matthew J Lesneski, Ying Xu, Caroline Low, Theresa Lu, Richard L Proia
& Jason G Cyster Published online: 06 June 2004|doi:10.1038/ni1083 Abstract|Full text|PDF
(2,037K)
See also:News and Views by Gunn & Kelsoe
Critical functions for c-Myb at three checkpoints during thymocyte developmentpp721 - 729 Timothy P Bender, Christopher S Kremer, Manfred Kraus, Thorsten Buch
& Klaus Rajewsky Published online: 13 June 2004|doi:10.1038/ni1085 Abstract|Full text|PDF
(1,190K)
|Supplementary Information
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsespp730 - 737 Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa, Noriaki Shinobu, Tadaatsu Imaizumi, Makoto Miyagishi, Kazunari Taira, Shizuo Akira
& Takashi Fujita Published online: 20 June 2004|doi:10.1038/ni1087 Abstract|Full text|PDF
(2,787K)
|Supplementary Information See also:News and Views by Levy & Marié
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacitypp738 - 743 Kristin J Hope, Liqing Jin
& John E Dick Published online: 30 May 2004|doi:10.1038/ni1080 Abstract|Full text|PDF
(1,907K)
See also:News and Views by Scadden
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophilspp744 - 751 Marie-Dominique Filippi, Chad E Harris, Jarek Meller, Yi Gu, Yi Zheng
& David A Williams Published online: 30 May 2004|doi:10.1038/ni1081 Abstract|Full text|PDF
(2,388K)
|Supplementary Information
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in micepp752 - 760 Stacey R Dillon, Cindy Sprecher, Angela Hammond, Janine Bilsborough, Maryland Rosenfeld-Franklin, Scott R Presnell, Harald S Haugen, Mark Maurer, Brandon Harder, Janet Johnston, Susan Bort, Sherri Mudri, Joseph L Kuijper, Tom Bukowski, Pamela Shea, Dennis L Dong, Maria Dasovich, Francis J Grant, Luann Lockwood, Steven D Levin, Cosette LeCiel, Kim Waggie, Heather Day, Stavros Topouzis, Janet Kramer, Rolf Kuestner, Zhi Chen, Don Foster, Julia Parrish-Novak
& Jane A Gross Published online: 06 June 2004|doi:10.1038/ni1084 Abstract|Full text|PDF
(1,061K)
|Supplementary Information
