Matthew A. Williams and Michael J. Bevan are in the Department of Immunology and Howard Hughes Medical Institute at the University of Washington, Seattle, Washington 98155, USA. mbevan@u.washington.edu
Contrary to results of previous studies using high frequencies of T cell receptor−transgenic T cells, new data indicate that when naive precursor frequencies approach endogenous levels, CD8+ effector and central memory T cell lineage commitment is fixed.
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