Nature Immunology
- 7, 1237 - 1242 (2006)
Published online: 16 November 2006; | doi:10.1038/ni1420
The innate signaling of dangers and the dangers of innate signalingPhilippe J Sansonetti
Unité de Pathogénie Microbienne Moléculaire, Unité INSERM 786, and the Howard Hughes Medical Institute International Program, Institut Pasteur, 75724 Paris, France.
Correspondence should be addressed to Philippe J Sansonetti psanson@pasteur.fr The innate immune system of mammals has been forged by coevolution with microbes in response to the double constraint of preserving a symbiotic interaction with commensal flora and eliminating intrusion of those commensals or invasion by pathogens. Thus, a 'sensing' network, accompanied by or lacking inflammatory responses, is controlled by elaborate mechanisms of regulation that maintain balance in the basal state. A growing number of non–Toll-like innate immune receptors is recognized as part of this surveillance network.
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