Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D Blackburn, Haina Shin, W Nicholas Haining, Tao Zou, Creg J Workman, Antonio Polley, Michael R Betts, Gordon J Freeman, Dario A A Vignali & E John Wherry
Published online: 30 November 2008; | doi:10.1038/ni.1679
Chronic infection can lead to T cell exhaustion. Wherry and colleagues demonstrate that a hierarchy of inhibitory receptors coregulate CD8+ T cell exhaustion during chronic viral infection.
Abstract - Coregulation of CD8: +: T cell exhaustion by multiple inhibitory receptors during chronic viral infection | Full Text - Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection | PDF (1,754 KB) - Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection | Supplementary information
Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells
Tom Cupedo, Natasha K Crellin, Natalie Papazian, Elwin J Rombouts, Kees Weijer, Jane L Grogan, Willem E Fibbe, Jan J Cornelissen & Hergen Spits
Published online: 23 November 2008; | doi:10.1038/ni.1668
Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor ROR
t. Cupedo's group identifies RORt+ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier and Diefenbach describe RORt-expressing interleukin 22–producing natural killer cells in mouse gut.
Abstract - Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to : RORC: +: CD127: +: natural killer-like cells | Full Text - Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells | PDF (597 KB) - Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells | Supplementary information
Influence of the transcription factor ROR
t on the development of NKp46+ cell populations in gut and skin
Carmelo Luci, Ana Reynders, Ivaylo I Ivanov, Celine Cognet, Laurent Chiche, Lionel Chasson, Jean Hardwigsen, Esperanza Anguiano, Jacques Banchereau, Damien Chaussabel, Marc Dalod, Dan R Littman, Eric Vivier & Elena Tomasello
Published online: 23 November 2008; | doi:10.1038/ni.1681
Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor RORt. Cupedo's group identifies RORt+ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier and Diefenbach describe RORt-expressing interleukin 22–producing natural killer cells in mouse gut.
Abstract - Influence of the transcription factor ROR[gamma]t on the development of NKp46: +: cell populations in gut and skin | Full Text - Influence of the transcription factor RORt on the development of NKp46+ cell populations in gut and skin | PDF (741 KB) - Influence of the transcription factor RORt on the development of NKp46+ cell populations in gut and skin | Supplementary information
RORt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells
Stephanie L Sanos, Viet L Bui, Arthur Mortha, Karin Oberle, Charlotte Heners, Caroline Johner & Andreas Diefenbach
Published online: 23 November 2008; | doi:10.1038/ni.1684
Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor RORt. Cupedo's group identifies RORt+ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier and Diefenbach describe RORt-expressing interleukin 22–producing natural killer cells in mouse gut.
Abstract - ROR[gamma]t and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46: +: cells | Full Text - RORt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells | PDF (647 KB) - RORt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells | Supplementary information
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
Alejandro Villagra, Fengdong Cheng, Hong-Wei Wang, Ildelfonso Suarez, Michelle Glozak, Michelle Maurin, Danny Nguyen, Kenneth L Wright, Peter W Atadja, Kapil Bhalla, Javier Pinilla-Ibarz, Edward Seto & Eduardo M Sotomayor
Published online: 16 November 2008; | doi:10.1038/ni.1673
Interleukin 10 dampens inflammation and prevents excessive tissue damage during immune responses. Sotomayor and colleagues show that the histone deacetylase HDAC11 negatively regulates expression of the gene encoding interleukin 10 and immune tolerance.
Abstract - The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance | Full Text - The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance | PDF (483 KB) - The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance | Supplementary information
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Xin Yu, Kristin Harden, Lino C Gonzalez, Michelle Francesco, Eugene Chiang, Bryan Irving, Irene Tom, Sinisa Ivelja, Canio J Refino, Hilary Clark, Dan Eaton & Jane L Grogan
Published online: 16 November 2008; | doi:10.1038/ni.1674
Dendritic cells (DCs) can promote or inhibit T cell responses. Grogan and colleagues show that the T cell protein TIGIT, by engaging poliovirus receptor on DCs, promotes DC interleukin 10 production, which inhibits T cell activation.
Abstract - The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells | Full Text - The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells | PDF (713 KB) - The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells | Supplementary information
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Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Troy D Querec, Rama S Akondy, Eva K Lee, Weiping Cao, Helder I Nakaya, Dirk Teuwen, Ali Pirani, Kim Gernert, Jiusheng Deng, Bruz Marzolf, Kathleen Kennedy, Haiyan Wu, Soumaya Bennouna, Herold Oluoch, Joseph Miller, Ricardo Z Vencio, Mark Mulligan, Alan Aderem, Rafi Ahmed & Bali Pulendran
Published online: 23 November 2008; | doi:10.1038/ni.1688
A major challenge for vaccinologists is to understand vaccine immunogenicity. Pulendran and colleagues use systems biology to determine gene 'signatures' that predict CD8+ T cell and antibody responses to the yellow fever vaccine.
Abstract - Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans | Full Text - Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans | PDF (698 KB) - Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Immunology advance online publication, day month year (doi:10.1038/niXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Immunology volume, page (year); advance online publication, (doi:10.1038/niXXXXX)".
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