Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationArticles
T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
Michael H Shaw, Thornik Reimer, Carmen Sánchez-Valdepeñas, Neil Warner, Yun-Gi Kim, Manuel Fresno & Gabriel Nuñez
Published online: 01 November 2009 | doi:10.1038/ni.1816
Nod2 senses intracellular bacteria and is required for their eradication. Nuñez and co-workers now describe a T cell–intrinsic role for Nod2 in combating the intracellular parasite Toxoplasma gondii.
Abstract - T cell-intrinsic role of Nod2 in promoting type 1 immunity to : Toxoplasma gondii | Full Text - T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii | PDF (1,666 KB) - T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii | Supplementary information
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
Xuexian O Yang, Pornpimon Angkasekwinai, Jinfang Zhu, Juan Peng, Zhiduo Liu, Roza Nurieva, Xikui Liu, Yeonseok Chung, Seon Hee Chang, Bing Sun & Chen Dong
Published online: 01 November 2009 | doi:10.1038/ni.1821
The molecular mediators responsible for directing T helper type 2 (TH2) differentiation remain incompletely defined. Dong and co-workers find that the transcription factor Dec2 promotes expression of the transcription factor JunB and is essential for the induction of TH2 responses.
Abstract - Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T: H: 2 lineage commitment | Full Text - Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment | PDF (566 KB) - Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment | Supplementary information
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
Fuping You, Hui Sun, Xiang Zhou, Wenxiang Sun, Shimin Liang, Zhonghe Zhai & Zhengfan Jiang
Published online: 01 November 2009 | doi:10.1038/ni.1815
The mitochondrial adaptor MAVS is necessary for the transmission of RIG-I and Mda5 antiviral signals. Jiang and colleagues show that PCBP2 negatively regulates MAVS stability by recruiting the L48-ubiquitinating enzyme AIP4, thereby preventing excessive cytokine responses.
Abstract - PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 | Full Text - PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 | PDF (1,771 KB) - PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 | Supplementary information
Multiple layers of B cell memory with different effector functions
Ismail Dogan, Barbara Bertocci, Valérie Vilmont, Frédéric Delbos, Jérome Mégret, Sébastien Storck, Claude-Agnès Reynaud & Jean-Claude Weill
Published online: 25 October 2009 | doi:10.1038/ni.1814
Immunization elicits B cell memory and short- and long-term antibody-secreting plasma cells. Weill and colleagues show that long-term IgM+ and IgG+ memory B cells can persist in germinal centers and undergo different fates after antigenic rechallenge.
Abstract - Multiple layers of B cell memory with different effector functions | Full Text - Multiple layers of B cell memory with different effector functions | PDF (1,265 KB) - Multiple layers of B cell memory with different effector functions | Supplementary information
Enteric defensins are essential regulators of intestinal microbial ecology
Nita H Salzman, Kuiechun Hung, Dipica Haribhai, Hiutung Chu, Jenny Karlsson-Sjöberg, Elad Amir, Paul Teggatz, Melissa Barman, Michael Hayward, Daniel Eastwood, Maaike Stoel, Yanjiao Zhou, Erica Sodergren, George M Weinstock, Charles L Bevins, Calvin B Williams & Nicolaas A Bos
Published online: 22 October 2009 | doi:10.1038/ni.1825
Defensins combat pathogenic bacteria invading the mammalian intestine. Salzman and co-workers find that defensins influence the composition of the small intestinal commensal microbiota and the presence of interleukin 17–producing T cells in the lamina propria.
Abstract - Enteric defensins are essential regulators of intestinal microbial ecology | Full Text - Enteric defensins are essential regulators of intestinal microbial ecology | PDF (923 KB) - Enteric defensins are essential regulators of intestinal microbial ecology | Supplementary information
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
Changsheng Du, Chang Liu, Jiuhong Kang, Guixian Zhao, Zhiqiang Ye, Shichao Huang, Zhenxin Li, Zhiying Wu & Gang Pei
Published online: 18 October 2009 | doi:10.1038/ni.1798
Interleukin 17 (IL-17)-producing helper T cells (TH-17 cells) are associated with the pathogenesis of multiple sclerosis. Pei and colleagues have now identified a TH-17 cell–associated microRNA, miR-326, whose expression correlates with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis.
Abstract - MicroRNA miR-326 regulates T: H: -17 differentiation and is associated with the pathogenesis of multiple sclerosis | Full Text - MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis | PDF (1,128 KB) - MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis | Supplementary information
Structural basis of receptor sharing by interleukin 17 cytokines
Lauren K Ely, Suzanne Fischer & K Christopher Garcia
Published online: 18 October 2009 | doi:10.1038/ni.1813
The interleukin 17 (IL-17) family includes six cytokines and five receptors. Garcia and co-workers solve the crystal structure of the receptor IL-17RA bound to IL-17F and suggest that IL-17RA may act as a shared subunit among multiple IL-17 receptor complexes.
Abstract - Structural basis of receptor sharing by interleukin 17 cytokines | Full Text - Structural basis of receptor sharing by interleukin 17 cytokines | PDF (1,192 KB) - Structural basis of receptor sharing by interleukin 17 cytokines | Supplementary information
Defective survival of naive CD8+ T lymphocytes in the absence of the 
3 regulatory subunit of voltage-gated calcium channels
Mithilesh K Jha, Abdallah Badou, Marcel Meissner, John E McRory, Marc Freichel, Veit Flockerzi & Richard A Flavell
Published online: 18 October 2009 | doi:10.1038/ni.1793
T cell activation triggers large calcium fluxes. Flavell and colleagues show tonic calcium signaling via Cav1.4-
3 channels are needed for the survival and homeostasis of naive CD8+ T cells.
Abstract - Defective survival of naive CD8: +: T lymphocytes in the absence of the [beta]3 regulatory subunit of voltage-gated calcium channels | Full Text - Defective survival of naive CD8+ T lymphocytes in the absence of the 3 regulatory subunit of voltage-gated calcium channels | PDF (1,792 KB) - Defective survival of naive CD8+ T lymphocytes in the absence of the 3 regulatory subunit of voltage-gated calcium channels |
Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Immunology advance online publication, day month year (doi:10.1038/niXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Immunology volume, page (year); advance online publication, (doi:10.1038/niXXXXX)".
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