Table of contents


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Editorials

Cold shower for AIDS vaccines pp1389 - 1390

doi:10.1038/nm1207-1389



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News

BBC apologizes for airing AIDS 'denialist' documentary p1391

Virginia Hughes

doi:10.1038/nm1207-1391


Spat over firing threatens medical school at US-Mexico border p1392

Brendan Borrell

doi:10.1038/nm1207-1392


Institutional changes may mean more resources for Indian scientists p1393

T. V. Padma

doi:10.1038/nm1207-1393


Polio eradication campaign copes with unusual outbreak p1394

Cassandra Willyard

doi:10.1038/nm1207-1394


Profile: Hugh Herr p1395

Cassandra Willyard

doi:10.1038/nm1207-1395


News in brief pp1396 - 1397

doi:10.1038/nm1207-1396


2007 in review

Yearbook p1398

doi:10.1038/nm1207-1398


Biomedicine in the headlines p1399

doi:10.1038/nm1207-1399


An eventful year for the FDA p1400

doi:10.1038/nm1207-1400


Notable advances p1401

doi:10.1038/nm1207-1401


Timeline of events p1402

doi:10.1038/nm1207-1402


Looking back p1403

doi:10.1038/nm1207-1403


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Correspondence

Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia pp1405 - 1406

Juliane Bubeck Wardenburg, Taeok Bae, Michael Otto, Frank R DeLeo & Olaf Schneewind

doi:10.1038/nm1207-1405

See also: News and Views by Lowy | Letter by Wang et al.


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Book Review

The stem cell controversy p1407

Clive N Svendsen reviews Renewing the stuff of life: Stem cells, ethics, and public policy by Cynthia B Cohen

doi:10.1038/nm1207-1407


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News and Views

Sensitive cilia set up the kidney pp1409 - 1411

Emily Kim & Gerd Walz

doi:10.1038/nm1207-1409

See also: Letter by Piontek et al.


Building the bionic T cell pp1411 - 1413

Drew M Pardoll

doi:10.1038/nm1207-1411

See also: Article by Stephan et al.


Dying T cells trigger autoimmunity in HIV pp1413 - 1415

Sarah Rowland-Jones & Tao Dong

doi:10.1038/nm1207-1413

See also: Article by Rawson et al.


Putting the heat on cancer pp1415 - 1417

Paul Workman & Emmanuel de Billy

doi:10.1038/nm1207-1415


Incapacitating the immune system in cystic fibrosis pp1417 - 1418

Ian Sabroe & Moira K B Whyte

doi:10.1038/nm1207-1417

See also: Article by Hartl et al.



Research Highlights pp1421 - 1422

doi:10.1038/nm1207-1421


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Articles

Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease pp1423 - 1430

Dominik Hartl, Philipp Latzin, Peter Hordijk, Veronica Marcos, Carsten Rudolph, Markus Woischnik, Susanne Krauss-Etschmann, Barbara Koller, Dietrich Reinhardt, Adelbert A Roscher, Dirk Roos & Matthias Griese

doi:10.1038/nm1690

See also: News and Views by Sabroe & Whyte


Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection pp1431 - 1439

Pisana Moroni Rawson, Caroline Molette, Melissa Videtta, Laura Altieri, Debora Franceschini, Tiziana Donato, Luigi Finocchi, Antonella Propato, Marino Paroli, Francesca Meloni, Claudio M Mastroianni, Gabriella d'Ettorre, John Sidney, Alessandro Sette & Vincenzo Barnaba

doi:10.1038/nm1679

See also: News and Views by Rowland-Jones & Dong


T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection pp1440 - 1449

Matthias T Stephan, Vladimir Ponomarev, Renier J Brentjens, Alex H Chang, Konstantin V Dobrenkov, Glenn Heller & Michel Sadelain

doi:10.1038/nm1676

See also: News and Views by Pardoll


A pivotal role for galectin-1 in fetomaternal tolerance pp1450 - 1457

Sandra M Blois, Juan M Ilarregui, Mareike Tometten, Mariana Garcia, Arif S Orsal, Rosalia Cordo-Russo, Marta A Toscano, Germán A Bianco, Peter Kobelt, Bori Handjiski, Irene Tirado, Udo R Markert, Burghard F Klapp, Francoise Poirier, Julia Szekeres-Bartho, Gabriel A Rabinovich & Petra C Arck

doi:10.1038/nm1680


Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation pp1458 - 1466

Tuomas Tammela, Anne Saaristo, Tanja Holopainen, Johannes Lyytikkä, Anna Kotronen, Miia Pitkonen, Usama Abo-Ramadan, Seppo Ylä-Herttuala, Tatiana V Petrova & Kari Alitalo

doi:10.1038/nm1689


Pim-1 regulates cardiomyocyte survival downstream of Akt pp1467 - 1475

John A Muraski, Marcello Rota, Yu Misao, Jenna Fransioli, Christopher Cottage, Natalie Gude, Grazia Esposito, Francesca Delucchi, Michael Arcarese, Roberto Alvarez, Sailay Siddiqi, Gregory N Emmanuel, Weitao Wu, Kimberlee Fischer, Joshua J Martindale, Christopher C Glembotski, Annarosa Leri, Jan Kajstura, Nancy Magnuson, Anton Berns, Remus M Beretta, Steven R Houser, Erik M Schaefer, Piero Anversa & Mark A Sussman

doi:10.1038/nm1671


Antidepressant actions of the exercise-regulated gene VGF pp1476 - 1482

Joshua G Hunsberger, Samuel S Newton, Alicia H Bennett, Catharine H Duman, David S Russell, Stephen R Salton & Ronald S Duman

doi:10.1038/nm1669


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Letters

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system pp1483 - 1489

Manuel A Friese, Matthew J Craner, Ruth Etzensperger, Sandra Vergo, John A Wemmie, Michael J Welsh, Angela Vincent & Lars Fugger

doi:10.1038/nm1668


A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1 pp1490 - 1495

Klaus Piontek, Luis F Menezes, Miguel A Garcia-Gonzalez, David L Huso & Gregory G Germino

doi:10.1038/nm1675

See also: News and Views by Kim & Walz


PPAR-bold gamma regulates osteoclastogenesis in mice pp1496 - 1503

Yihong Wan, Ling-Wa Chong & Ronald M Evans

doi:10.1038/nm1672


The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation pp1504 - 1509

Yien Che Tsai, Arnulfo Mendoza, Jennifer M Mariano, Ming Zhou, Zlatka Kostova, Bo Chen, Timothy Veenstra, Stephen M Hewitt, Lee J Helman, Chand Khanna & Allan M Weissman

doi:10.1038/nm1686


Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA pp1510 - 1514

Rong Wang, Kevin R Braughton, Dorothee Kretschmer, Thanh-Huy L Bach, Shu Y Queck, Min Li, Adam D Kennedy, David W Dorward, Seymour J Klebanoff, Andreas Peschel, Frank R DeLeo & Michael Otto

doi:10.1038/nm1656

See also: Correspondence by Bubeck Wardenburg et al. | News and Views by Lowy


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Technical Report

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice pp1515 - 1520

Sheetal Gandotra, Dirk Schnappinger, Mercedes Monteleone, Wolfgang Hillen & Sabine Ehrt

doi:10.1038/nm1683


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Erratum

Erratum: Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy p1521

Sam E Day, Mikko I Kettunen, Ferdia A Gallagher, De-En Hu, Mathilde Lerche, Jan Wolber, Klaes Golman, Jan Henrik Ardenkjaer-Larsen & Kevin M Brindle

doi:10.1038/nm1207-1521


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