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News and Views
Nature Medicine 13, 126 - 128 (2007)
doi:10.1038/nm0207-126
Orexins: looking forward to sleep, back at addiction
Thomas E Scammell1 & Clifford B Saper1
- The authors are in the Department of Neurology, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. e-mail: tscammel@bidmc.harvard.edu
Abstract
An orally available drug enters the brain and interferes with signaling of orexin neuropeptides—providing a potential treatment for sleep disorders and possibly addiction (pages 150–155).
The Roman god Janus displays two faces, one looking back and the other toward what lies ahead. Like Janus, we can look back over the last several years and appreciate how much we have learned about the roles of the orexin neuropeptides in the regulation of wakefulness and sleep, the control of body weight and metabolism, and the regulation of motivation and addiction1.
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