1. The authors are in the Molecular Mycobacteriology Research Unit and Centre of Excellence for Biomedical Tuberculosis Research, School of Pathology, University of the Witwatersrand and National Health Laboratory Service, de Korte Street, Johannesburg 2000, South Africa. e-mail: mizrahiv@pathology.wits.ac.za

Abstract

Persistence of Mycobacterium tuberculosis in humans depends on its ability to survive within the host macrophage. So the bacterium must resist antimicrobial mechanisms or subvert macrophage signaling pathways to prevent its death. Recent evidence suggests that the two strategies are not mutually exclusive.

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