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News and Views
Nature Medicine 13, 245 - 246 (2007)
doi:10.1038/nm0307-245
Langerhans cells lap up HIV-1
Olivier Schwartz1
- Olivier Schwartz is in the Groupe Virus et Immunité, Centre National de la Recherche Scientifique (CNRS), URA3015, Institut Pasteur, Paris, 75015 France. e-mail: schwartz@pasteur.fr
Abstract
Langerhans cells in the skin and mucosa have been thought to mediate the spread of HIV-1 in the body during sexual transmission. Instead, it seems that the cells protect against the virus, a finding with implications for the development of microbicides (pages 367–371).
Paul Langerhans, a German medical student, was 21 when he described in 1868 a new epidermal cell type which now bears his name. The cells have long dendrites, so Langerhans regarded them as a component of the nervous system1.
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