Table of contents
Focus
Focus on Tuberculosis
- Focus issue:
- March 2007 Volume 13, No 3
In what direction is the field of tuberculosis going? By bringing together input from top scientists, analysts and decision makers interested in tuberculosis research, this focus identifies the recent papers with the most impact in the discipline and identifies the key issues that are shaping our thinking in this field.
Editorial
Too little, too late? - p225
doi:10.1038/nm0307-225
Abstract - Too little, too late? | Full Text - Too little, too late? | PDF (63 KB) - Too little, too late?
News
Trials race rashly ahead for regulatory immune cells - p227
Douglas Braaten
doi:10.1038/nm0307-227
Abstract - Trials race rashly ahead for regulatory immune cells | Full Text - Trials race rashly ahead for regulatory immune cells | PDF (189 KB) - Trials race rashly ahead for regulatory immune cells
Infrastructure, biotech top African science summit agenda - p228
Christina Scott
doi:10.1038/nm0307-228a
Abstract - Infrastructure, biotech top African science summit agenda | Full Text - Infrastructure, biotech top African science summit agenda | PDF (169 KB) - Infrastructure, biotech top African science summit agenda
Biomedical research faces flat budget for 2008 - pp228 - 229
Alan Dove
doi:10.1038/nm0307-228b
Abstract - Biomedical research faces flat budget for 2008 | Full Text - Biomedical research faces flat budget for 2008 | PDF (359 KB) - Biomedical research faces flat budget for 2008
Activists protest National Parks proposal to profit from microbes - p229
Alisa Opar
doi:10.1038/nm0307-229
Abstract - Activists protest National Parks proposal to profit from microbes | Full Text - Activists protest National Parks proposal to profit from microbes | PDF (257 KB) - Activists protest National Parks proposal to profit from microbes
Canceled conference puts conflicts of interest under scrutiny - p230
Brandon Keim
doi:10.1038/nm0307-230a
Abstract - Canceled conference puts conflicts of interest under scrutiny | Full Text - Canceled conference puts conflicts of interest under scrutiny | PDF (99 KB) - Canceled conference puts conflicts of interest under scrutiny
AIDS gel's failure calls prevention approach into question - p230
Natasha Bolognesi
doi:10.1038/nm0307-230b
Abstract - AIDS gel's failure calls prevention approach into question | Full Text - AIDS gel's failure calls prevention approach into question | PDF (99 KB) - AIDS gel's failure calls prevention approach into question
News feature: WikiMedia - pp231 - 233
Brandon Keim
doi:10.1038/nm0307-231
Abstract - News feature: WikiMedia | Full Text - News feature: WikiMedia | PDF (886 KB) - News feature: WikiMedia
News in brief - pp234 - 235
doi:10.1038/nm0307-234
Correspondence
Do biomarkers trump behavior? - p237
Olavo B Amaral
doi:10.1038/nm0307-237a
Full Text - Do biomarkers trump behavior? | PDF (61 KB) - Do biomarkers trump behavior?
Reply to 'Alice Dautry' profile - p237
António Bandeira, Françoise Barré-Sinoussi, Pierre-André Cazenave, Stewart Cole, Ana Cumano, James Di Santo, Nicole Guiso, Alain Israël, Pablo Pereira & Paulo Vieira
doi:10.1038/nm0307-237b
Full Text - Reply to 'Alice Dautry' profile | PDF (68 KB) - Reply to 'Alice Dautry' profile
Book Review
Plagues and people meet the microbe hunters - p239
doi:10.1038/nm0307-239
Full Text - Plagues and people meet the microbe hunters | PDF (90 KB) - Plagues and people meet the microbe hunters
News and Views
The ABCs of 
-cell dysfunction in type 2 diabetes - pp241 - 242
Manu V Chakravarthy & Clay F Semenkovich
doi:10.1038/nm0307-241
Abstract - The ABCs of [beta]-cell dysfunction in type 2 diabetes | Full Text - The ABCs of 
-cell dysfunction in type 2 diabetes | PDF (219 KB) - The ABCs of -cell dysfunction in type 2 diabetes
See also: Article by Brunham et al.
Cracking the cytokine code in psoriasis - pp242 - 244
Brian J Nickoloff
doi:10.1038/nm0307-242
Abstract - Cracking the cytokine code in psoriasis | Full Text - Cracking the cytokine code in psoriasis | PDF (1,592 KB) - Cracking the cytokine code in psoriasis
Skin safety - p244
Charlotte Schubert
doi:10.1038/nm0307-244
Langerhans cells lap up HIV-1 - pp245 - 246
Olivier Schwartz
doi:10.1038/nm0307-245
Abstract - Langerhans cells lap up HIV-1 | Full Text - Langerhans cells lap up HIV-1 | PDF (274 KB) - Langerhans cells lap up HIV-1
See also: Letter by de Witte et al.
Long-distance affair with adrenal GRK2 hangs up heart failure - pp246 - 248
Stephen B Liggett
doi:10.1038/nm0307-246
Abstract - Long-distance affair with adrenal GRK2 hangs up heart failure | Full Text - Long-distance affair with adrenal GRK2 hangs up heart failure | PDF (288 KB) - Long-distance affair with adrenal GRK2 hangs up heart failure
See also: Article by Lymperopoulos et al.
Vaccine leads to memory loss - pp248 - 250
John B A G Haanen & Ton N M Schumacher
doi:10.1038/nm0307-248
Abstract - Vaccine leads to memory loss | Full Text - Vaccine leads to memory loss | PDF (256 KB) - Vaccine leads to memory loss
See also: Article by Berner et al.
Regulatory T-cell development: is Foxp3 the decider? - pp250 - 253
Tyler J Curiel
doi:10.1038/nm0307-250
Abstract - Regulatory T-cell development: is Foxp3 the decider? | Full Text - Regulatory T-cell development: is Foxp3 the decider? | PDF (463 KB) - Regulatory T-cell development: is Foxp3 the decider?
A plague upon fibrin - pp253 - 254
Richard W Titball & Petra C F Oyston
doi:10.1038/nm0307-253
Abstract - A plague upon fibrin | Full Text - A plague upon fibrin | PDF (268 KB) - A plague upon fibrin
Research highlights - p255
doi:10.1038/nm0307-255
Full Text - Research highlights | PDF (143 KB) - Research highlights
News
Tuberculosis
Unlikely partners tackle TB funding woes - p265
Erika Check
doi:10.1038/nm0307-265
Abstract - Unlikely partners tackle TB funding woes | Full Text - Unlikely partners tackle TB funding woes | PDF (124 KB) - Unlikely partners tackle TB funding woes
Tuberculosis
After decades of drought, new drug possibilities flood TB pipeline - p266
Erika Check
doi:10.1038/nm0307-266
Abstract - After decades of drought, new drug possibilities flood TB pipeline | Full Text - After decades of drought, new drug possibilities flood TB pipeline | PDF (518 KB) - After decades of drought, new drug possibilities flood TB pipeline
Tuberculosis
From TB tests, just a 'yes or no' answer, please - p267
Emma Marris
doi:10.1038/nm0307-267
Abstract - From TB tests, just a 'yes or no' answer, please | Full Text - From TB tests, just a 'yes or no' answer, please | PDF (129 KB) - From TB tests, just a 'yes or no' answer, please
Tuberculosis
News feature: A clash of cultures - pp268 - 270
Apoorva Mandavilli
doi:10.1038/nm0307-268
Abstract - News feature: A clash of cultures | Full Text - News feature: A clash of cultures | PDF (218 KB) - News feature: A clash of cultures
Tuberculosis
Health agency pulls back on 'patronizing' approach to TB treatment - p269
Apoorva Mandavilli
doi:10.1038/nm0307-269
Abstract - Health agency pulls back on 'patronizing' approach to TB treatment | Full Text - Health agency pulls back on 'patronizing' approach to TB treatment | PDF (136 KB) - Health agency pulls back on 'patronizing' approach to TB treatment
Tuberculosis
Spotlight on... Mark Harrington - p270
Alisa Opar
doi:10.1038/nm0307-270
Abstract - Spotlight on... Mark Harrington | Full Text - Spotlight on... Mark Harrington | PDF (113 KB) - Spotlight on... Mark Harrington
Tuberculosis
Virtually incurable TB warns of impending disaster - p271
Apoorva Mandavilli
doi:10.1038/nm0307-271a
Abstract - Virtually incurable TB warns of impending disaster | Full Text - Virtually incurable TB warns of impending disaster | PDF (133 KB) - Virtually incurable TB warns of impending disaster
Tuberculosis
Spotlight on... Ken Duncan - p271
Alisa Opar
doi:10.1038/nm0307-271b
Abstract - Spotlight on... Ken Duncan | Full Text - Spotlight on... Ken Duncan | PDF (133 KB) - Spotlight on... Ken Duncan
Tuberculosis
News feature: Trials and tribulations - pp272 - 273
Apoorva Mandavilli
doi:10.1038/nm0307-272
Abstract - News feature: Trials and tribulations | Full Text - News feature: Trials and tribulations | PDF (207 KB) - News feature: Trials and tribulations
Tuberculosis
Spotlight on... Mario Raviglione - p273
Brandon Keim
doi:10.1038/nm0307-273
Abstract - Spotlight on... Mario Raviglione | Full Text - Spotlight on... Mario Raviglione | PDF (173 KB) - Spotlight on... Mario Raviglione
Tuberculosis
A dozen vaccine candidates bring shot of hope to TB epidemic - p274
Emma Marris
doi:10.1038/nm0307-274a
Abstract - A dozen vaccine candidates bring shot of hope to TB epidemic | Full Text - A dozen vaccine candidates bring shot of hope to TB epidemic | PDF (96 KB) - A dozen vaccine candidates bring shot of hope to TB epidemic
Tuberculosis
When the vaccine causes disease - p274
Apoorva Mandavilli
doi:10.1038/nm0307-274b
Abstract - When the vaccine causes disease | Full Text - When the vaccine causes disease | PDF (96 KB) - When the vaccine causes disease
Tuberculosis
Profile: Wafaa El-Sadr - p275
Apoorva Mandavilli
doi:10.1038/nm0307-275
Abstract - Profile: Wafaa El-Sadr | Full Text - Profile: Wafaa El-Sadr | PDF (96 KB) - Profile: Wafaa El-Sadr
Analysis
Tuberculosis
The top twenty papers on tuberculosis - pp276 - 277
doi:10.1038/nm0307-276
Abstract - The top twenty papers on tuberculosis | Full Text - The top twenty papers on tuberculosis | PDF (175 KB) - The top twenty papers on tuberculosis
Tuberculosis
Highly cited papers on tuberculosis (2003–2005) - p278
doi:10.1038/nm0307-278
Full Text - Highly cited papers on tuberculosis (2003–2005) | PDF (92 KB) - Highly cited papers on tuberculosis (2003–2005)
News and Views
Tuberculosis
The open book of infectious diseases - pp279 - 280
Christopher M Sassetti & Eric J Rubin
doi:10.1038/nm0307-279
Abstract - The open book of infectious diseases | Full Text - The open book of infectious diseases | PDF (149 KB) - The open book of infectious diseases
Tuberculosis
Defining the 'survivasome' of Mycobacterium tuberculosis - pp280 - 282
Gyanu Lamichhane & William Bishai
doi:10.1038/nm0307-280
Abstract - Defining the 'survivasome' of Mycobacterium tuberculosis | Full Text - Defining the 'survivasome' of Mycobacterium tuberculosis | PDF (167 KB) - Defining the 'survivasome' of Mycobacterium tuberculosis
Tuberculosis
The survival kit of Mycobacterium tuberculosis - pp282 - 284
Digby F Warner & Valerie Mizrahi
doi:10.1038/nm0307-282
Abstract - The survival kit of Mycobacterium tuberculosis | Full Text - The survival kit of Mycobacterium tuberculosis | PDF (186 KB) - The survival kit of Mycobacterium tuberculosis
Tuberculosis
Mycobacterium tuberculosis virulence: lipids inside and out - pp284 - 285
Sabine Ehrt & Dirk Schnappinger
doi:10.1038/nm0307-284
Abstract - Mycobacterium tuberculosis virulence: lipids inside and out | Full Text - Mycobacterium tuberculosis virulence: lipids inside and out | PDF (136 KB) - Mycobacterium tuberculosis virulence: lipids inside and out
Tuberculosis
Mycobacterial virulence and specialized secretion: same story, different ending - pp286 - 287
Marcel A Behr & David R Sherman
doi:10.1038/nm0307-286
Abstract - Mycobacterial virulence and specialized secretion: same story, different ending | Full Text - Mycobacterial virulence and specialized secretion: same story, different ending | PDF (145 KB) - Mycobacterial virulence and specialized secretion: same story, different ending
Research highlights - pp288 - 289
doi:10.1038/nm0307-288
Full Text - Research highlights | PDF (285 KB) - Research highlights
Commentaries
Tuberculosis
Challenges in tuberculosis drug research and development - pp290 - 294
Ann M Ginsberg & Melvin Spigelman
doi:10.1038/nm0307-290
Full Text - Challenges in tuberculosis drug research and development | PDF (107 KB) - Challenges in tuberculosis drug research and development
Tuberculosis
From magic bullets back to the Magic Mountain: the rise of extensively drug-resistant tuberculosis - pp295 - 298
Susan E Dorman & Richard E Chaisson
doi:10.1038/nm0307-295
Full Text - From magic bullets back to the Magic Mountain: the rise of extensively drug-resistant tuberculosis | PDF (272 KB) - From magic bullets back to the Magic Mountain: the rise of extensively drug-resistant tuberculosis
Tuberculosis
Changing funding patterns in tuberculosis - pp299 - 303
Stefan H E Kaufmann & Shreemanta K Parida
doi:10.1038/nm0307-299
Full Text - Changing funding patterns in tuberculosis | PDF (194 KB) - Changing funding patterns in tuberculosis
Tuberculosis
Aligning pharmaceutical innovation with medical need - pp304 - 308
Carl Nathan
doi:10.1038/nm0307-304
Full Text - Aligning pharmaceutical innovation with medical need | PDF (141 KB) - Aligning pharmaceutical innovation with medical need
Market Analysis
Tuberculosis
Tuberculosis, a neglected opportunity? - pp309 - 312
Claire Harper
doi:10.1038/nm0307-309
Full Text - Tuberculosis, a neglected opportunity? | PDF (471 KB) - Tuberculosis, a neglected opportunity?
Articles
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure - pp315 - 323
Anastasios Lymperopoulos, Giuseppe Rengo, Hajime Funakoshi, Andrea D Eckhart & Walter J Koch
doi:10.1038/nm1553
Abstract - Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure | Full Text - Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure | PDF (398 KB) - Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure | Supplementary information
See also: News and Views by Liggett
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 activity - pp324 - 331
Chinmay M Trivedi, Yang Luo, Zhan Yin, Maozhen Zhang, Wenting Zhu, Tao Wang, Thomas Floss, Martin Goettlicher, Patricia Ruiz Noppinger, Wolfgang Wurst, Victor A Ferrari, Charles S Abrams, Peter J Gruber & Jonathan A Epstein
doi:10.1038/nm1552
Abstract - Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3[beta] activity | Full Text - Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 activity | PDF (557 KB) - Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 activity | Supplementary information
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions - pp332 - 339
Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, Masaki Kobayashi, Takeshi Takazawa, Masato Iwabu, Miki Okada-Iwabu, Sachiko Kawamoto, Naoto Kubota, Tetsuya Kubota, Yusuke Ito, Junji Kamon, Atsushi Tsuchida, Katsuyoshi Kumagai, Hideki Kozono, Yusuke Hada, Hitomi Ogata, Kumpei Tokuyama, Masaki Tsunoda, Tomohiro Ide, Kouji Murakami, Motoharu Awazawa, Iseki Takamoto, Philippe Froguel, Kazuo Hara, Kazuyuki Tobe, Ryozo Nagai, Kohjiro Ueki & Takashi Kadowaki
doi:10.1038/nm1557
Abstract - Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions | Full Text - Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions | PDF (378 KB) - Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions | Supplementary information
-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment - pp340 - 347
Liam R Brunham, Janine K Kruit, Terry D Pape, Jenelle M Timmins, Anne Q Reuwer, Zainisha Vasanji, Brad J Marsh, Brian Rodrigues, James D Johnson, John S Parks, C Bruce Verchere & Michael R Hayden
doi:10.1038/nm1546
Abstract - [beta]-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment | Full Text - -cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment | PDF (308 KB) - -cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment | Supplementary information
ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor - pp348 - 353
Zhiming Yang, Yu-Jia Chang, I-Chen Yu, Shuyuan Yeh, Cheng-Chia Wu, Hiroshi Miyamoto, Diane E Merry, Gen Sobue, Lu-Min Chen, Shu-Shi Chang & Chawnshang Chang
doi:10.1038/nm1547
Abstract - ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor | Full Text - ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor | PDF (356 KB) - ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor | Supplementary information
IFN-
mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy - pp354 - 360
Vanessa Berner, Haiyan Liu, Qing Zhou, Kory L Alderson, Kai Sun, Jonathan M Weiss, Timothy C Back, Dan L Longo, Bruce R Blazar, Robert H Wiltrout, Lisbeth A Welniak, Doug Redelman & William J Murphy
doi:10.1038/nm1554
Abstract - IFN-[gamma] mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy | Full Text - IFN-
mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy | PDF (695 KB) - IFN- mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy | Supplementary information
See also: News and Views by Haanen & Schumacher
Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer - pp361 - 366
Avrum Spira, Jennifer E Beane, Vishal Shah, Katrina Steiling, Gang Liu, Frank Schembri, Sean Gilman, Yves-Martine Dumas, Paul Calner, Paola Sebastiani, Sriram Sridhar, John Beamis, Carla Lamb, Timothy Anderson, Norman Gerry, Joseph Keane, Marc E Lenburg & Jerome S Brody
doi:10.1038/nm1556
Abstract - Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer | Full Text - Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer | PDF (259 KB) - Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer | Supplementary information
Letter
Langerin is a natural barrier to HIV-1 transmission by Langerhans cells - pp367 - 371
Lot de Witte, Alexey Nabatov, Marjorie Pion, Donna Fluitsma, Marein A W P de Jong, Tanja de Gruijl, Vincent Piguet, Yvette van Kooyk & Teunis B H Geijtenbeek
doi:10.1038/nm1541
First paragraph - Langerin is a natural barrier to HIV-1 transmission by Langerhans cells | Full Text - Langerin is a natural barrier to HIV-1 transmission by Langerhans cells | PDF (295 KB) - Langerin is a natural barrier to HIV-1 transmission by Langerhans cells | Supplementary information
See also: News and Views by Schwartz
Technical Reports
In vivo imaging of siRNA delivery and silencing in tumors - pp372 - 377
Zdravka Medarova, Wellington Pham, Christian Farrar, Victoria Petkova & Anna Moore
doi:10.1038/nm1486
Abstract - In vivo imaging of siRNA delivery and silencing in tumors | Full Text - In vivo imaging of siRNA delivery and silencing in tumors | PDF (456 KB) - In vivo imaging of siRNA delivery and silencing in tumors | Supplementary information
Humanization of autoantigen - pp378 - 383
Wataru Nishie, Daisuke Sawamura, Maki Goto, Kei Ito, Akihiko Shibaki, James R McMillan, Kaori Sakai, Hideki Nakamura, Edit Olasz, Kim B Yancey, Masashi Akiyama & Hiroshi Shimizu
doi:10.1038/nm1496
Abstract - Humanization of autoantigen | Full Text - Humanization of autoantigen | PDF (570 KB) - Humanization of autoantigen | Supplementary information
Erratum
Erratum: A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage - p385
Lawrence Steinman
doi:10.1038/nm0307-385a
Full Text - Erratum: A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage | PDF (47 KB) - Erratum: A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage
Corrigendum
Corrigendum: Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes - p385
Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal & Steven A Goldman
doi:10.1038/nm0307-385b
Full Text - Corrigendum: Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes | PDF (47 KB) - Corrigendum: Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
