Needles galore, but no place to sew - p387

doi:10.1038/nm0407-387

Abstract - Needles galore, but no place to sew | Full Text - Needles galore, but no place to sew | PDF (65 KB) - Needles galore, but no place to sew

Changes to US drug safety laws take center stage - p389

Meredith Wadman

doi:10.1038/nm0407-389

Abstract - Changes to US drug safety laws take center stage | Full Text - Changes to US drug safety laws take center stage | PDF (268 KB) - Changes to US drug safety laws take center stage

Nifty transport device doubles durability of donor organs - p390

Alan Dove

doi:10.1038/nm0407-390a

Abstract - Nifty transport device doubles durability of donor organs | Full Text - Nifty transport device doubles durability of donor organs | PDF (189 KB) - Nifty transport device doubles durability of donor organs

Critics slam Russian trial to test pig pancreas for diabetics - pp390 - 391

Simon Grose

doi:10.1038/nm0407-390b

Abstract - Critics slam Russian trial to test pig pancreas for diabetics | Full Text - Critics slam Russian trial to test pig pancreas for diabetics | PDF (246 KB) - Critics slam Russian trial to test pig pancreas for diabetics

Pricey cancer genome project struggles with sample shortage - p391

Emily Waltz

doi:10.1038/nm0407-391

Abstract - Pricey cancer genome project struggles with sample shortage | Full Text - Pricey cancer genome project struggles with sample shortage | PDF (107 KB) - Pricey cancer genome project struggles with sample shortage

Plagiarized report on patent laws shames Indian scientists - p392

T.V. Padma

doi:10.1038/nm0407-392a

Abstract - Plagiarized report on patent laws shames Indian scientists | Full Text - Plagiarized report on patent laws shames Indian scientists | PDF (137 KB) - Plagiarized report on patent laws shames Indian scientists

Controversy over cervical cancer vaccine spurs safety surveillance - pp392 - 393

Brandon Keim

doi:10.1038/nm0407-392b

Abstract - Controversy over cervical cancer vaccine spurs safety surveillance | Full Text - Controversy over cervical cancer vaccine spurs safety surveillance | PDF (220 KB) - Controversy over cervical cancer vaccine spurs safety surveillance

Aggressive drug marketing tactics trigger backlash - p393

Emily Singer

doi:10.1038/nm0407-393

Abstract - Aggressive drug marketing tactics trigger backlash | Full Text - Aggressive drug marketing tactics trigger backlash | PDF (110 KB) - Aggressive drug marketing tactics trigger backlash

News in brief - pp394 - 395

doi:10.1038/nm0407-394

Full Text - News in brief | PDF (477 KB) - News in brief

News feature: The sunshine cure - pp396 - 397

Apoorva Mandavilli

doi:10.1038/nm0407-396

Abstract - News feature: The sunshine cure | Full Text - News feature: The sunshine cure | PDF (222 KB) - News feature: The sunshine cure

Q & A: Straight talk from... Robert Klein - p398

Erika Check

doi:10.1038/nm0407-398

Abstract - Q & A: Straight talk from... Robert Klein | Full Text - Q & A: Straight talk from... Robert Klein | PDF (96 KB) - Q & A: Straight talk from... Robert Klein

NMR-based prediction of cardiovascular risk in diabetes - pp399 - 400

Ronan Roussel, France Mentré, Nadia Bouchemal, Samy Hadjadj, Michel Lièvre, Gilles Chatellier, Joël Menard, Xavière Panhard, Anne Le Hénanff, Michel Marre & Laurence Le Moyec

doi:10.1038/nm0407-399

Full Text - NMR-based prediction of cardiovascular risk in diabetes | PDF (80 KB) - NMR-based prediction of cardiovascular risk in diabetes

On race and organ markets - p401

doi:10.1038/nm0407-401

Full Text - On race and organ markets | PDF (78 KB) - On race and organ markets

Netting bacteria in sepsis - pp403 - 404

Constantin Urban & Arturo Zychlinsky

doi:10.1038/nm0407-403

Abstract - Netting bacteria in sepsis | Full Text - Netting bacteria in sepsis | PDF (1,136 KB) - Netting bacteria in sepsis

See also: Article by Clark et al.

Providing AID to p53 mutagenesis - pp404 - 406

Shigeo Takaishi & Timothy C Wang

doi:10.1038/nm0407-404

Abstract - Providing AID to p53 mutagenesis | Full Text - Providing AID to p53 mutagenesis | PDF (546 KB) - Providing AID to p53 mutagenesis

See also: Article by Matsumoto et al.

Lung turns to AA (adenosine analogues) to dry out - pp406 - 408

James L Kreindler & Steven D Shapiro

doi:10.1038/nm0407-406

Abstract - Lung turns to AA (adenosine analogues) to dry out | Full Text - Lung turns to AA (adenosine analogues) to dry out | PDF (220 KB) - Lung turns to AA (adenosine analogues) to dry out

Immune cells may fend off Alzheimer disease - pp408 - 409

Markus Britschgi & Tony Wyss-Coray

doi:10.1038/nm0407-408

Abstract - Immune cells may fend off Alzheimer disease | Full Text - Immune cells may fend off Alzheimer disease | PDF (414 KB) - Immune cells may fend off Alzheimer disease

See also: Article by El Khoury et al.

MicroRNA may have macro effect on sudden death - pp410 - 411

Mark E Anderson & Peter J Mohler

doi:10.1038/nm0407-410

Abstract - MicroRNA may have macro effect on sudden death | Full Text - MicroRNA may have macro effect on sudden death | PDF (201 KB) - MicroRNA may have macro effect on sudden death

See also: Letter by Yang et al.

T effectors outfox T regulators in autoimmunity - pp411 - 413

Thomas Prod'homme, Martin S Weber & Scott S Zamvil

doi:10.1038/nm0407-411

Abstract - T effectors outfox T regulators in autoimmunity | Full Text - T effectors outfox T regulators in autoimmunity | PDF (305 KB) - T effectors outfox T regulators in autoimmunity

See also: Article by Korn et al.

Premature poking: impulsivity, cocaine and dopamine - pp413 - 414

George Uhl

doi:10.1038/nm0407-413

Abstract - Premature poking: impulsivity, cocaine and dopamine | Full Text - Premature poking: impulsivity, cocaine and dopamine | PDF (224 KB) - Premature poking: impulsivity, cocaine and dopamine

Research highlights - pp416 - 417

doi:10.1038/nm0407-416

Full Text - Research highlights | PDF (254 KB) - Research highlights

CD8⁺ T-cell responses to adeno-associated virus capsid in humans - pp419 - 422

Federico Mingozzi, Marcela V Maus, Daniel J Hui, Denise E Sabatino, Samuel L Murphy, John E J Rasko, Margaret V Ragni, Catherine S Manno, Jurg Sommer, Haiyan Jiang, Glenn F Pierce, Hildegund C J Ertl & Katherine A High

doi:10.1038/nm1549

Abstract - CD8: +: T-cell responses to adeno-associated virus capsid in humans | Full Text - CD8+ T-cell responses to adeno-associated virus capsid in humans | PDF (234 KB) - CD8+ T-cell responses to adeno-associated virus capsid in humans | Supplementary information

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation - pp423 - 431

Thomas Korn, Jayagopala Reddy, Wenda Gao, Estelle Bettelli, Amit Awasthi, Troels R Petersen, B Thomas Bäckström, Raymond A Sobel, Kai W Wucherpfennig, Terry B Strom, Mohamed Oukka & Vijay K Kuchroo

doi:10.1038/nm1564

Abstract - Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation | Full Text - Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation | PDF (414 KB) - Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation | Supplementary information

See also: News and Views by Prod'homme et al.

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease - pp432 - 438

Joseph El Khoury, Michelle Toft, Suzanne E Hickman, Terry K Means, Kinya Terada, Changiz Geula & Andrew D Luster

doi:10.1038/nm1555

Abstract - Ccr2: deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease | Full Text - Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease | PDF (473 KB) - Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease | Supplementary information

See also: News and Views by Britschgi & Wyss-Coray

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease - pp439 - 447

Jean-Pyo Lee, Mylvaganam Jeyakumar, Rodolfo Gonzalez, Hiroto Takahashi, Pei-Jen Lee, Rena C Baek, Dan Clark, Heather Rose, Gerald Fu, Jonathan Clarke, Scott McKercher, Jennifer Meerloo, Franz-Josef Muller, Kook In Park, Terry D Butters, Raymond A Dwek, Philip Schwartz, Gang Tong, David Wenger, Stuart A Lipton, Thomas N Seyfried, Frances M Platt & Evan Y Snyder

doi:10.1038/nm1548

Abstract - Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease | Full Text - Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease | PDF (580 KB) - Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease | Supplementary information

Ca²⁺ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 - pp448 - 454

Susanne Ludwiczek, Igor Theurl, Martina U Muckenthaler, Martin Jakab, Sabine M Mair, Milan Theurl, Judit Kiss, Markus Paulmichl, Matthias W Hentze, Markus Ritter & Guenter Weiss

doi:10.1038/nm1542

Abstract - Ca: 2+: channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 | Full Text - Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 | PDF (484 KB) - Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 | Supplementary information

Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance - pp455 - 462

Lisa A Lesniewski, Sarah E Hosch, Jaap G Neels, Carl de Luca, Mohammad Pashmforoush, Carey N Lumeng, Shian-Huey Chiang, Miriam Scadeng, Alan R Saltiel & Jerrold M Olefsky

doi:10.1038/nm1550

Abstract - Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance | Full Text - Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance | PDF (381 KB) - Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance | Supplementary information

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood - pp463 - 469

Stephen R Clark, Adrienne C Ma, Samantha A Tavener, Braedon McDonald, Zahra Goodarzi, Margaret M Kelly, Kamala D Patel, Subhadeep Chakrabarti, Erin McAvoy, Gary D Sinclair, Elizabeth M Keys, Emma Allen-Vercoe, Rebekah DeVinney, Christopher J Doig, Francis H Y Green & Paul Kubes

doi:10.1038/nm1565

Abstract - Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood | Full Text - Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood | PDF (303 KB) - Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood | Supplementary information

See also: News and Views by Urban & Zychlinsky

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium - pp470 - 476

Yuko Matsumoto, Hiroyuki Marusawa, Kazuo Kinoshita, Yoko Endo, Tadayuki Kou, Toshiyuki Morisawa, Takeshi Azuma, Il-Mi Okazaki, Tasuku Honjo & Tsutomu Chiba

doi:10.1038/nm1566

Abstract - Helicobacter pylori: infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium | Full Text - Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium | PDF (563 KB) - Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium | Supplementary information

See also: News and Views by Takaishi & Wang

Angiogenic inhibition reduces germinal matrix hemorrhage - pp477 - 485

Praveen Ballabh, Hongmin Xu, Furong Hu, Alex Braun, Kira Smith, Aracelie Rivera, Nanhong Lou, Zoltan Ungvari, Steven A Goldman, Anna Csiszar & Maiken Nedergaard

doi:10.1038/nm1558

Abstract - Angiogenic inhibition reduces germinal matrix hemorrhage | Full Text - Angiogenic inhibition reduces germinal matrix hemorrhage | PDF (470 KB) - Angiogenic inhibition reduces germinal matrix hemorrhage | Supplementary information

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 - pp486 - 491

Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Ying Zhang, Chaoqian Xu, Yunlong Bai, Huizhen Wang, Guohao Chen & Zhiguo Wang

doi:10.1038/nm1569

First paragraph - The muscle-specific microRNA : miR-1: regulates cardiac arrhythmogenic potential by targeting : GJA1: and : KCNJ2 | Full Text - The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 | PDF (268 KB) - The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 | Supplementary information

See also: News and Views by Anderson & Mohler

Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB₁ on neurons and CB₂ on autoreactive T cells - pp492 - 497

Katarzyna Maresz, Gareth Pryce, Eugene D Ponomarev, Giovanni Marsicano, J Ludovic Croxford, Leah P Shriver, Catherine Ledent, Xiaodong Cheng, Erica J Carrier, Monica K Mann, Gavin Giovannoni, Roger G Pertwee, Takashi Yamamura, Nancy E Buckley, Cecilia J Hillard, Beat Lutz, David Baker & Bonnie N Dittel

doi:10.1038/nm1561

First paragraph - Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB: 1: on neurons and CB: 2: on autoreactive T cells | Full Text - Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells | PDF (255 KB) - Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells | Supplementary information

MRI detection of transcriptional regulation of gene expression in transgenic mice - pp498 - 503

Batya Cohen, Keren Ziv, Vicki Plaks, Tomer Israely, Vyacheslav Kalchenko, Alon Harmelin, Laura E Benjamin & Michal Neeman

doi:10.1038/nm1497

Abstract - MRI detection of transcriptional regulation of gene expression in transgenic mice | Full Text - MRI detection of transcriptional regulation of gene expression in transgenic mice | PDF (477 KB) - MRI detection of transcriptional regulation of gene expression in transgenic mice | Supplementary information

Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes - pp504 - 509

Marina V Backer, Zoya Levashova, Vimalkumar Patel, Brian T Jehning, Kevin Claffey, Francis G Blankenberg & Joseph M Backer

doi:10.1038/nm1522

Abstract - Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes | Full Text - Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes | PDF (504 KB) - Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes | Supplementary information

Corrigendum: Angiotensin II type 1 receptor blockade attenuates TGF-–induced failure of muscle regeneration in multiple myopathic states - p511

Ronald D Cohn, Christel van Erp, Jennifer P Habashi, Arshia A Soleimani, Erin C Klein, Matthew T Lisi, Matthew Gamradt, Colette M ap Rhys, Tammy M Holm, Bart L Loeys, Francesco Ramirez, Daniel P Judge, Christopher W Ward & Harry C Dietz

doi:10.1038/nm0407-511a

Full Text - Corrigendum: Angiotensin II type 1 receptor blockade attenuates TGF-–induced failure of muscle regeneration in multiple myopathic states | PDF (258 KB) - Corrigendum: Angiotensin II type 1 receptor blockade attenuates TGF-–induced failure of muscle regeneration in multiple myopathic states

Addendum: VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo - p511

Elizabeth A Harrington, David Bebbington, Jeff Moore, Richele K Rasmussen, Abi O Ajose-Adeogun, Tomoko Nakayama, Joanne A Graham, Cecile Demur, Thierry Hercend, Anita Diu-Hercend, Michael Su, Julian M C Golec & Karen M Miller

doi:10.1038/nm0407-511b

Full Text - Addendum: VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo | PDF (258 KB) - Addendum: VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo