1. Richard N. Kitsis is in the Departments of Medicine, and Cell Biology, and at the Cardiovascular Research Center, and Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA. e-mail: kitsis@aecom.yu.edu
2. Chang-Fu Peng is in the Department of Medicine, and at the Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
3. Ana Maria Cuervo is in the Departments of Anatomy and Structural Biology, Medicine, and Developmental and Molecular Biology, and at the Marion Bessin Liver Research Center, and Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Abstract

The presence of autophagic morphology in failing heart muscle cells has suggested that autophagy causes heart failure. Instead, it seems that the opposite is true: autophagy is critical for normal heart function (pages 619–624).

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