1. Howard Y. Chang is in the Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA e-mail: howchang@stanford.edu
2. George Cotsarelis is in the Dept. of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. e-mail: cotsarel@mail.med.upenn.edu

Abstract

Introducing four genes into mouse skin fibroblasts reprograms these cells into embryonic stem cells. If similar techniques work in human cells, patient-specific stem cells for tissue engineering and cell-based therapies may be closer to reality.

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