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Nature Medicine 13, 1015 - 1016 (2007)
doi:10.1038/nm0907-1015
The clot thickens—oxidized lipids and thrombosis
Shaun P Jackson1 & Anna C Calkin2
- Shaun P. Jackson is at the Australian Centre for Blood Diseases, Monash University, Melbourne, Australia. e-mail: shaun.jackson@med.monash.edu.au
- Anna C. Calkin is at the Baker Heart Research Institute, Alfred Medical Research & Education Precinct, Melbourne, Australia. e-mail: anna.calkin@baker.edu.au
Abstract
Oxidized products of low-density lipoproteins (LDLs) activate platelets through CD36, demonstrating a link between deregulated lipoprotein levels, oxidative stress and thrombosis (pages 1086–1095).
One of the major obstacles to increased longevity is atherosclerosis, an inflammatory disorder that leads to fibrous, fatty lesions in the arterial wall. Advanced atherosclerotic lesions (plaques) are prone to rupture, exposing thrombogenic elements that promote excessive platelet and fibrin accumulation, leading to the formation of arterial thrombi (clots).
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RESEARCH
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotypeNature Medicine Article (01 Sep 2007)
