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Nature Medicine 14, 1311 - 1313 (2008)
doi:10.1038/nm1208-1311
Saving the skin from drug-induced detachment
Brian J Nickoloff1
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Brian J. Nickoloff is at the Loyola University of Chicago Medical Center, Building 112, Room 301, 2160 South First Avenue, Maywood, Illinois 60153-5385, USA.
e-mail: bnickol@lumc.edu
Abstract
Granulysin, a powerful cytolytic protein secreted from immune cells, underlies an extreme and deadly response to common medications, in which the skin blisters and sloughs off. The findings may also have implications for bone marrow transplant recipients suffering from graft-versus-host disease (pages 1343–1350).
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Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysisNature Medicine Letter (01 Dec 2008)
Evaluation of the Potential Role of Cytokines in Toxic Epidermal NecrolysisJournal of Investigative Dermatology Original Article
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