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Nature Medicine 14, 1319-1320 (1 December 2008) | doi:10.1038/nm1208-1319;
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Abstract
The pattern-recognition receptors of the innate immune system, such as Toll-like receptors, bind specific repetitive components of microbes, including lipoproteins, lipopolysaccharides and nucleic acids. The location of some of these receptors in distinct subcellular compartments facilitates detection of intracellular pathogens but presumably precludes activation by self molecules that are structural homologs of microbial ligands.
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