1. Lisette M. Acevedo, Sara M. Weis and David A. Cheresh are in the Department of Pathology and the Moores University of California–San Diego Cancer Center, University of California, San Diego, La Jolla, California 92093-0803, USA. e-mail: dcheresh@ucsd.edu

Abstract

Robo4 expression in emerging blood vessels can neutralize signaling through the angiogenic factor vascular endothelial growth factor (VEGF) and maintain vessel integrity. The findings could lead to new therapeutic targets for angiogenesis and vascular leakage (pages 448–453).

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