1. Division of Endocrinology, Beth-Isreal Deaconess Medical Center, Harvard Medical School, Boston Massachusetts, 02215, USA. e-mail: emaratos@bidmc.harvard.edu

Abstract

The energy-regulating hormone leptin affects signals emerging from certain brain regions. New results explore the nature of these signals, finding a central role for phosphoinositide-3 kinase in the brain and the endocannabinoid system in adipocytes (pages 667–675).

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