Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 14, 910 - 912 (2008)
doi:10.1038/nm0908-910
Mitochondrial missile defense
Victor Nizet1 & Marc E Rothenberg1
- Victor Nizet is in the Department of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0687 La Jolla, California 92093 and at the Rady Children's Hospital 3020 Children's Way, San Diego, California 92123, USA.
e-mail: vnizet@ucsd.edu - Marc E. Rothenberg is in the Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue MLC7028, Cincinnati, Ohio 45229, USA.
e-mail: rothenberg@cchmc.org.
Abstract
A relatively obscure immune cell, the eosinophil, has a dramatic way of defending against pathogens. It rapidly ejects mitochondrial DNA, ensnaring bacteria and hastening their demise (pages 949–953).
Eosinophils, a specialized granulocytic cell type derived from the bone marrow, are a biological and medical enigma. Recent attention has focused upon these curious cells with the emergence of a series of gastrointestinal disorders now referred to as eosinophil-associated gastrointestinal disorders (EGIDs)1.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
28 years of high-dose therapy and SCT for neuroblastoma in Europe: lessons from more than 4000 proceduresBone Marrow Transplantation Original Article
