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Nature Medicine 8, 927 - 928 (2002)
doi:10.1038/nm0902-927
The makings of a killer
Peter Palese1, Christopher F. Basler1 & Adolfo García-Sastre1
- Department of Microbiology Mount Sinai School of Medicine New York, New York, USA e-mail: peter.palese@mssm.edu
Abstract
The 1997 flu in Hong Kong infected only 18 patients, but killed 6 of them. Now, reverse genetics experiments have pinpointed the NS1 gene as a primary culprit.
In 1997 a highly lethal influenza virus made the leap from birds to humans in Hong Kong. It killed 6 out of a total of 18 patients before culling of the local poultry prevented the possibility of additional transmission to humans.
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