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The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).

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Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

Stephanie Lefèvre, Anette Knedla, Christoph Tennie, Andreas Kampmann, Christina Wunrau, Robert Dinser, Adelheid Korb, Eva-Maria Schnäker, Ingo H Tarner, Paul D Robbins, Christopher H Evans, Henning Stürz, Jürgen Steinmeyer, Steffen Gay, Jürgen Schölmerich, Thomas Pap, Ulf Müller-Ladner & Elena Neumann

Published online: 08 November 2009 | doi:10.1038/nm.2050

Rheumatoid arthritis usually begins in one joint but spreads to other joints as the disease progresses. Elena Neumann and her colleagues show that rheumatoid arthritis synovial fibroblasts (RASFs) may be key mediators of this process. They show, using a SCID mouse model, that human RASFs can migrate long distances through the bloodstream from diseased cartilage to unaffected cartilage, where they can mount a new attack.


Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

Daniel T Starczynowski, Florian Kuchenbauer, Bob Argiropoulos, Sandy Sung, Ryan Morin, Andrew Muranyi, Martin Hirst, Donna Hogge, Marco Marra, Richard A Wells, Rena Buckstein, Wan Lam, R Keith Humphries & Aly Karsan

Published online: 08 November 2009 | doi:10.1038/nm.2054

For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al. provide evidence that decreased expression of two miRNAs in this region—miR-145 and miR-146a—contributes to abnormal megakaryocyte differentiation and platelet production and progression of the disease to either bone marrow failure or leukemia. The authors also provide a mechanistic explanation for these effects by which loss of these two miRNAs leads to derepression of innate immune signaling.


Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Medicine advance online publication, day month year (doi:10.1038/nmXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Medicine volume, page (year); advance online publication, (doi:10.1038/nmXXXXX)".

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