Method of the Year 2008

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In 2007, Nature Methods Editors started what they intended as an end-of-year tradition: the selection of a Method of the Year. The 2007 winner was next-generation sequencing, selected because we felt this method came into its own in 2007 and had a wide-ranging impact. This year, we are seeking your input in helping us select the Method of the Year 2008. On this site you will be able to nominate candidate methods and to vote and comment on suggestions by others. Use this form to recommend a method (you will need to provide a link to a paper or other online description of the method). To kick-start your thinking, we have listed last year's selection of Methods to Watch. Vote away!

• 6 votes

  Biotechnology

  • • 2+ votes

      4- votes

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  • Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster

    • 
      Original article citation: Nat Meth 5, 49-51, (2008).

    • Categories: Biotechnology and Genetics and genomics
    • Recommended by: Jianquan Ni on 11/10/2008 08:16PM GMT
    • Comment on this subject: 0 comments made

• 13 votes

  Genetics and genomics

  • • 9+ votes

      4- votes

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  • Tools for neuroanatomy and neurogenetics in Drosophila

    • 
      Original article citation: Proceedings of the National Academy of Sciences 105, 9715-9720,

    • Categories: Genetics and genomics and Neuroscience
    • Recommended by: Terry Vale on 11/08/2008 11:25PM GMT
    • Comment on this subject: 0 comments made

• 17 votes

  Systems biology

  • • 11+ votes

      6- votes

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  • The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

    • 
      Original article citation: Genome Biol 9, R127, (2008).

    • Categories: Systems biology and Genetics and genomics
    • Recommended by: Amanda Zhou on 10/31/2008 09:01AM GMT
    • Comment on this subject: 0 comments made

• 10 votes

  Proteomics

  • • 5+ votes

      5- votes

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  • Dynamic Screening Experiments to Maximize Hits for Crystallization†

    • 
      Original article citation: Cryst. Growth Des. 7, 2171-2175, (2007).

    • Categories: Proteomics
    • Recommended by: Emmanuel Saridakis on 10/28/2008 01:03PM GMT
    • Comment on this subject: 0 comments made

• 8 votes

  Protein biochemistry

  • • 3+ votes

      5- votes

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  • GPCR Engineering Yields High-Resolution Structural Insights into 2-Adrenergic Receptor Function

    • 
      Original article citation: Science 318, 1266-1273, (2007).

    • Categories: Protein biochemistry
    • Recommended by: Naomi Chayen on 10/28/2008 12:48PM GMT
    • Comment on this subject: 0 comments made

• 28 votes

  Cell biology

  • • 14+ votes

      14- votes

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  • Global identification of microRNA–target RNA pairs by parallel analysis of RNA ends

    • Marcelo A German, Manoj Pillay, Dong-Hoon Jeong, Amit Hetawal, Shujun Luo, Prakash Janardhanan, Vimal Kannan, Linda A Rymarquis, Kan Nobuta, Rana German, Emanuele De Paoli, Cheng Lu, Gary Schroth, Blake C Meyers, Pamela J Green
      Original article citation: Nat Biotechnol 26, 941-946, (2008).

    • Categories: Cell biology, Biotechnology, and Systems biology
    • Recommended by: Marcelo German on 09/18/2008 08:10PM GMT
    • Comment on this subject: 0 comments made

• 21 votes

  Systems biology

  • • 9+ votes

      12- votes

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  • WikiPathways: Pathway Editing for the People

    • Alexander R. Pico, Thomas Kelder, Martijn P. van Iersel, Kristina Hanspers, Bruce R. Conklin, Chris Evelo
      Original article citation: Plos Biol 6, e184, (2008).

    • Categories: Systems biology and Genetics and genomics
    • Recommended by: Thomas Kelder on 09/18/2008 07:57AM GMT
    • Comment on this subject: 0 comments made

• 67 votes

  Proteomics

  • • 45+ votes

      22- votes

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  • Direct observation of individual endogenous protein complexes in situ by proximity ligation

    • Ola Söderberg, Mats Gullberg, Malin Jarvius, Karin Ridderstråle, Karl-Johan Leuchowius, Jonas Jarvius, Kenneth Wester, Per Hydbring, Fuad Bahram, Lars-Gunnar Larsson, Ulf Landegren
      Original article citation: Nat Meth 3, 995-1000, (2006).

    • Categories: Proteomics, Biotechnology, Cell biology, and Imaging
    • Recommended by: Olle Ericsson on 09/15/2008 02:56PM GMT
    • Comment on this subject: 0 comments made

• 59 votes

  Proteomics

  • • 44+ votes

      15- votes

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  • Straightforward ladder sequencing of peptides using a Lys-N metalloendopeptidase

    • Nadia Taouatas, Madalina M Drugan, Albert J R Heck, Shabaz Mohammed
      Original article citation: Nat Meth 5, 405-407, (2008).

    • Categories: Proteomics
    • Recommended by: Silvia Surinova on 09/15/2008 12:43PM GMT
    • Comment on this subject: 0 comments made

• 12 votes

  Proteomics

  • • 5+ votes

      7- votes

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  • Global Mapping of the Topography and Magnitude of Proteolytic Events in Apoptosis

    • M DIX
      Original article citation: Cell 134, 679-691, (2008).

    • Categories: Proteomics, Protein biochemistry, and Systems biology
    • Recommended by: gabe simon on 09/13/2008 03:15PM GMT
    • Comment on this subject: 0 comments made

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