NPG library
Below is a selection of News and Views, Research Highlights, Reviews, Research Articles, Perspectives and Commentaries published by Nature Publishing Group journals on the topic of Targeting Angiogenesis.
Research highlights
Cell migration: The importance of being selective
Ekat Kritikou
doi:10.1038/nrm2422
Nature Reviews Molecular Cell Biology 9, 426-427 (2008)
Angiogenesis: Blood born killer?
Nicola McCarthy
doi:10.1038/nrc2330
Nature Reviews Cancer 8, 164-165 (2008)
Anticancer drugs: Antisense angiogenesis inhibition
Man Tsuey Tse
doi:10.1038/nrd2534
Nature Reviews Drug Discovery 7, 202-203 (2008)
Translation: Switching to cap-independence
Sarah Seton-Rogers
doi:10.1038/nrc2303
Nature Reviews Cancer 8, 6-7 (2008)
Cancer: Tuning anti-angiogenesis
Bethan Hughes
doi:10.1038/nrd2495
Nature Reviews Drug Discovery 7, 18-19 (2008)
Angiogenesis: Another target
Sarah Seton-Rogers
doi:10.1038/nrc2283
Nature Reviews Cancer 7, 894-895 (2007)
Angiogenesis: Hidden signatures written in blood
Rebecca Robey
doi:10.1038/nrc2199
Nature Reviews Cancer 7, 571 (2007)
Angiogenesis: Less is more
Sarah Seton-Rogers
doi:10.1038/nrc2076
Nature Reviews Cancer 7, 71 (2007)
Angiogenesis: Blunting the spikes
Ezzie Hutchinson
doi:10.1038/nrc2018
Nature Reviews Cancer 6, 833 (2006)
Angiogenesis: Moving downstream
Sarah Seton-Rogers
doi:10.1038/nrc2002
Nature Reviews Cancer 6, 750 (2006)
Angiogenesis: Sneaky switch
Edward Wawrzynczak
doi:10.1038/nrc1993
Nature Reviews Cancer 6, 746 (2006)
Viral Tumorigenesis: Viral hijacking
Francesca Pentimalli
doi:10.1038/nrc1998
Nature Reviews Cancer 6, 748 (2006)
Tumorigenesis: Stress and cancer
Patrick Goymer
doi:10.1038/nrc1986
Nature Reviews Cancer 6, 658-659 (2006)
Vaccines: Provoking a response
Ezzie Hutchinson
doi:10.1038/nrc1938
Nature Reviews Cancer 6, 490-491 (2006)
News and Views
Robo4 counteracts VEGF signaling
Lisette M. Acevedo, Sara M. Weis & David A. Cheresh
doi:10.1038/nm0408-372
Nature Medicine 14, 372-373 (2008)
A hypoxic twist in metastasis
Héctor Peinado & Amparo Cano
doi:10.1038/ncb0308-253
Nature Cell Biology 10, 253-254 (2008)
Building in resistance to endothelial cell death
Massimiliano Mazzone, Carmen Ruiz de Almodovar & Peter Carmeliet
doi:10.1038/ng1107-1308
Nature Genetics 39, 1308-1309 (2007)
Vascular Biology: Vessel guidance
Thomas Gridley
doi:10.1038/445722a
Nature 445, 722-723 (2007)
Progress
Making a tumour's bed: glioblastoma stem cells and the vascular niche
Richard J. Gilbertson & Jeremy N. Rich
doi:10.1038/nrc2246
Nature Reviews Cancer 7, 733-736 (2007)
Glioblastoma stem cells might be dependent on cues from aberrant vascular niches that mimic the normal neural stem cell niche. What are the implications of these findings for treatment of this disease?
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
Gavin Thurston, Irene Noguera-Troise & George D. Yancopoulos
doi:10.1038/nrc2130
Nature Reviews Cancer 7, 327-331 (2007)
Several recent papers have shown that the Delta-like ligand 4 (Dll4)-Notch system restrains angiogenesis but, paradoxically, Dll4 inhibition decreases tumour growth. Is too much angiogenesis actually a good thing?
Reviews
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao & Benjamin Moeller
doi:10.1038/nrc2397
Nature Reviews Cancer 8, 425-437 (2008)
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, alter the activity of the transcription factor HIF1, which can regulate tumour cell survival and angiogenesis. Intratumoural heterogeneity of these factors significantly affects HIF1 and consequently the response to cytotoxic therapy.
Models, mechanisms and clinical evidence for cancer dormancy
Julio A. Aguirre-Ghiso
doi:10.1038/nrc2256
Nature Reviews Cancer 7, 834-846 (2007)
Cancer dormancy is a very important yet poorly understood phenomenon in cancer progression. What do we know about the mechanisms of cancer dormancy and can it be targeted therapeutically?
Extracellular control of TGF
signalling in vascular development and disease
Peter ten Dijke & Helen M. Arthur
doi:10.1038/nrm2262
Nature Reviews Molecular Cell Biology 8, 857-869 (2007)
Recent studies of human genetic syndromes and transgenic
mouse models with vascular pathology have exposed a crucial function
of extracellular control in the regulation of TGF
bioavailability in the vascular system. This Review discusses such
regulation and the implications of defects in this process with regards
to human health.
Molecular basis for sunitinib efficacy and future clinical development
Sandrine Faivre, George Demetri, William Sargent & Eric Raymond
doi:10.1038/nrd2380
Nature Reviews Drug Discovery 6, 734-745 (2007)
Sunitinib is a multitargeted kinase inhibitor that has recently been approved for the treatment of advanced renal cell carcinoma and gastrointestinal stromal tumours. Raymond and colleagues summarize the discovery and development of sunitinib, and discuss key issues for the multitargeted approach in cancer treatment, such as markers of response and development of resistance.
The role of junctional adhesion molecules in vascular inflammation
Christian Weber, Line Fraemohs & Elisabetta Dejana
doi:10.1038/nri2096
Nature Reviews Immunology 7, 467-477 (2007)
Recent studies have elucidated important roles for members of the junctional adhesion molecule (JAM) family in controlling vascular permeability and leukocyte transmigration. Christian Weber and colleagues highlight the role of JAMs as gate keepers in inflammation and vascular pathology.
Molecular regulation of angiogenesis and lymphangiogenesis
Ralf H. Adams & Kari Alitalo
doi:10.1038/nrm2183
Nature Reviews Molecular Cell Biology 8, 464-478 (2007)
The growth of the blood and lymphatic systems provides an excellent example for the tight coordination of diverse cellular processes during tissue morphogenesis. Elucidation of the molecular players and their roles in the development of endothelial networks will also provide insights into human disease.
Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
Thomas Force, Daniela S. Krause & Richard A. Van Etten
doi:10.1038/nrc2106
Nature Reviews Cancer 7, 332-344 (2007)
Although inhibition of tyrosine kinases has revolutionized cancer therapy, some of the inhibitors used have now been associated with cardiotoxicity. How does inhibition of cancer-relevant signalling pathways affect heart cells, and how can these effects be minimized?
The multifaceted circulating endothelial cell in cancer: towards marker and target identification
Francesco Bertolini, Yuval Shaked, Patrizia Mancuso & Robert S. Kerbel
doi:10.1038/nrc1971
Nature Reviews Cancer 6, 835-845 (2006)
The number of circulating endothelial cells and their progenitors is increased in some types of cancer, and there is evidence that aspects of these cells might correlate with clinical outcome of cancer patients treated with anti-angiogenic drugs.
Predicting benefit from anti-angiogenic agents in malignancy
Adrian M. Jubb, Adam J. Oates, Scott Holden & Hartmut Koeppen
doi:10.1038/nrc1946
Nature Reviews Cancer 6, 626-635 (2006)
Biomarkers used in determining the response to cytotoxic agents are not optimal for predicting benefit from anti-angiogenic drugs. Which anti-angiogenic biomarkers might prove useful for identifying initial drug choice, appropriate dosing, early clinical benefit, emerging resistance and second-line treatments?
Perspectives
The scientific contributions of M. Judah Folkman to cancer research
Bruce R. Zetter
doi:10.1038/nrc2458
Nature Reviews Cancer 8, 647-654 (2008)
Dr Judah Folkman was frequently described as a highly compassionate physician who served his patients not only by performing surgery and offering them comfort and reassurance, but also by working tirelessly in the laboratory to find new approaches to the treatment of disease.
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
Rakesh K. Jain
doi:10.1038/nrc2346
Nature Reviews Cancer 8, 309-316 (2008)
Making multidisciplinary translational clinical trials work successfully is complex and challenging. Rakesh Jain presents his perspective on the lessons he and his team have learned from two such trials in patients with advanced rectal cancer or glioblastoma.
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
Henk. M. W. Verheul & Herbert M. Pinedo
doi:10.1038/nrc2152
Nature Reviews Cancer 7, 475-485 (2007)
Angiogenesis inhibitors are now being used in the treatment of patients with cancer. However, these agents can lead to toxicities. This Perspective discusses these toxicities and the possible molecular mechanisms behind them.
Angiogenesis: an organizing principle for drug discovery?
Judah Folkman
doi:10.1038/nrd2115
Nature Reviews Drug Discovery 6, 273-286 (2007)
Pathological angiogenesis plays a role in a wide range of diseases. Folkman argues that viewing angiogenesis as an 'organizing principle' in biology can lead to novel insights into the molecular mechanisms of seemingly unrelated phenomena, and facilitate the development of new therapeutic approaches.
Research articles
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela, Georgia Zarkada, Elisabet Wallgard, Aino Murtomäki, Steven Suchting, Maria Wirzenius, Marika Waltari, Mats Hellström, Tibor Schomber, Reetta Peltonen, Catarina Freitas, Antonio Duarte, Helena Isoniemi, Pirjo Laakkonen, Gerhard Christofori, Seppo Ylä-Herttuala, Masabumi Shibuya, Bronislaw Pytowski, Anne Eichmann, Christer Betsholtz, Kari Alitalo
doi:10.1038/nature07083
Nature advance online publication 25 June 2008
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah, Manfred Jugold, Fabian Kiessling, Paul Rigby, Mitali Manzur, Hugo H. Marti, Tamer Rabie, Sylvia Kaden, Hermann-Josef Gröne, Günter J. Hämmerling, Bernd Arnold & Ruth Ganss
doi:10.1038/nature06868
Nature 453, 410-414 (2008)
Angiogenesis selectively requires the p110
isoform of PI3K to control endothelial cell migration
Mariona Graupera, Julie Guillermet-Guibert, Lazaros C. Foukas, Li-Kun Phng, Robert J. Cain, Ashreena Salpekar, Wayne Pearce, Stephen Meek, Jaime Millan, Pedro R. Cutillas, Andrew J. H. Smith, Anne J. Ridley, Christiana Ruhrberg, Holger Gerhardt & Bart Vanhaesebroeck
doi:10.1038/nature06892
Nature 453, 662-666 (2008)
Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1
Shigetomo Fukuhara, Keisuke Sako, Takashi Minami, Kazuomi Noda, Hak Zoo Kim, Tatsuhiko Kodama, Masabumi Shibuya, Nobuyuki Takakura, Gou Young Koh & Naoki Mochizuki
doi:10.1038/ncb1714
Nature Cell Biology 10, 513-526 (2008)
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts
Pipsa Saharinen, Lauri Eklund, Juho Miettinen, Riikka Wirkkala, Andrey Anisimov, Mark Winderlich, Astrid Nottebaum, Dietmar Vestweber, Urban Deutsch, Gou Young Koh, Bjorn R. Olsen & Kari Alitalo
doi:10.1038/ncb1715
Nature Cell Biology 10, 527-537 (2008)
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
Christopher A. Jones, Nyall R. London, Haoyu Chen, Kye Won Park, Dominique Sauvaget, Rebecca A. Stockton, Joshua D. Wythe, Wonhee Suh, Frederic Larrieu-Lahargue, Yoh-suke Mukouyama, Per Lindblom, Pankaj Seth, Antonio Frias, Naoyuki Nishiya, Mark H. Ginsberg, Holger Gerhardt, Kang Zhang & Dean Y. Li
doi:10.1038/nm1742
Nature Medicine 14, 448-453 (2008)
Perivascular nitric oxide gradients normalize tumor vasculature
Satoshi Kashiwagi, Kosuke Tsukada, Lei Xu, Junichi Miyazaki, Sergey V. Kozin, James A. Tyrrell, William C. Sessa, Leo E. Gerweck, Rakesh K. Jain & Dai Fukumura
doi:10.1038/nm1730
Nature Medicine 14, 255-257 (2008)
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
Tomoya Kitamura, Naoya Asai, Atsushi Enomoto, Kengo Maeda, Takuya Kato, Maki Ishida, Ping Jiang, Takashi Watanabe, Jiro Usukura, Takahisa Kondo, Frank Costantini, Toyoaki Murohara & Masahide Takahashi
doi:10.1038/ncb1695
Nature Cell Biology 10, 329-337 (2008)
Direct regulation of TWIST by HIF-1α promotes metastasis
Muh-Hwa Yang, Min-Zu Wu, Shih-Hwa Chiou, Po-Min Chen, Shyue-Yih Chang, Chung-Ji Liu, Shu-Chun Teng & Kou-Juey Wu
doi:10.1038/ncb1691
Nature Cell Biology 10, 295-305 (2008)
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
Arthur P. Young, Susanne Schlisio, Yoji Andrew Minamishima, Qing Zhang, Lianjie Li, Chiara Grisanzio, Sabina Signoretti & William G. Kaelin, Jr
doi:10.1038/ncb1699
Nature Cell Biology 10, 361-369 (2008)
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
Julián Aragonés, Martin Schneider, Katie Van Geyte, Peter Fraisl, Tom Dresselaers, Massimiliano Mazzone, Ruud Dirkx, Serena Zacchigna, Hélène Lemieux, Nam Ho Jeoung, Diether Lambrechts, Tammie Bishop, Peggy Lafuste, Antonio Diez-Juan, Sarah K. Harten, Pieter Van Noten, Katrien De Bock, Carsten Willam, Marc Tjwa, Alexandra Grosfeld, Rachel Navet, Lieve Moons, Thierry Vandendriessche, Christophe Deroose, Bhathiya Wijeyekoon, Johan Nuyts, Benedicte Jordan, Robert Silasi-Mansat, Florea Lupu, Mieke Dewerchin, Chris Pugh, Phil Salmon, Luc Mortelmans, Bernard Gallez, Frans Gorus, Johan Buyse, Francis Sluse, Robert A. Harris, Erich Gnaiger, Peter Hespel, Paul Van Hecke, Frans Schuit, Paul Van Veldhoven, Peter Ratcliffe, Myriam Baes, Patrick Maxwell & Peter Carmeliet
doi:10.1038/ng.2007.62
Nature Genetics 40, 170-180 (2008)
Widespread microRNA repression by Myc contributes to tumorigenesis
Tsung-Cheng Chang, Duonan Yu, Yun-Sil Lee, Erik A. Wentzel, Dan E. Arking, Kristin M. West, Chi V. Dang, Andrei Thomas-Tikhonenko & Joshua T. Mendell
doi:10.1038/ng.2007.30
Nature Genetics 40, 43-50 (2008)
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
Farbod Shojaei, Xiumin Wu, Cuiling Zhong, Lanlan Yu, Xiao-Huan Liang, Jenny Yao, Dominique Blanchard, Carlos Bais, Franklin V. Peale, Nicholas van Bruggen, Calvin Ho, Jed Ross, Martha Tan, Richard A. D. Carano, Y. Gloria Meng & Napoleone Ferrara
doi:10.1038/nature06348
Nature 450, 825-831 (2007)
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
Massimo M. Santoro, Temesgen Samuel, Tracy Mitchell, John C. Reed & Didier Y. R. Stainier
doi:10.1038/ng.2007.8
Nature Genetics 39, 1397-1402 (2007)
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Laura Soucek, Elizabeth R. Lawlor, Darya Soto, Ksenya Shchors, Lamorna Brown Swigart & Gerard I. Evan
doi:10.1038/nm1649
Nature Medicine 13, 1211-1218 (2007)
Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes
Marina V. Backer, Zoya Levashova, Vimalkumar Patel, Brian T. Jehning, Kevin Claffey, Francis G. Blankenberg & Joseph M. Backer
doi:10.1038/nm1522
Nature Medicine 13, 504-509 (2007)
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J. Watts, Christopher Callahan, Ian Kasman, Mallika Singh, May Chien, Christine Tan, Jo-Anne S. Hongo, Fred de Sauvage, Greg Plowman & Minhong Yan
doi:10.1038/nature05313
Nature 444, 1083-1087 (2006)
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos & Gavin Thurston
doi:10.1038/nature05355
Nature 444, 1032-1037 (2006)
PML inhibits HIF-1
translation and neoangiogenesis through repression of mTOR
Rosa Bernardi, Ilhem Guernah, David Jin, Silvia Grisendi, Andrea Alimonti, Julie Teruya-Feldstein, Carlos Cordon-Cardo, M. Celeste Simon, Shahin Rafii & Pier Paolo Pandolfi
doi:10.1038/nature05029
Nature 442, 779-785 (2006)
