Table of contents
From the editors
p733 | doi:10.1038/nrc2520
Research Highlights
Therapy: Developmental parallels | PDF (171 KB)
p735 | doi:10.1038/nrc2517
Tumorigenesis: Understanding one's origins | PDF (150 KB)
p736 | doi:10.1038/nrc2506
Therapy: Combine and conquer | PDF (140 KB)
p736 | doi:10.1038/nrc2519
RNA biology: There's nothing abnormal about chimeric RNA | PDF (140 KB)
p737 | doi:10.1038/nrc2511
Tumorigenesis: Taking the MYC | PDF (168 KB)
p738 | doi:10.1038/nrc2508
Evolution: Deep down | PDF (152 KB)
p738 | doi:10.1038/nrc2509
In the news
All clear for now | PDF (99 KB)
p738 | doi:10.1038/nrc2518
In brief
Metastasis | Oncogenes | Signalling | PDF (126 KB)
p739 | doi:10.1038/nrc2515
Cell division: Back and forth | PDF (155 KB)
p740 | doi:10.1038/nrc2514
Trial Watch
Skin Deep | Global risk and incidence | PDF (131 KB)
p740 | doi:10.1038/nrc2516
Epigenetics: Rewriting the ending | PDF (134 KB)
p741 | doi:10.1038/nrc2512
Metastasis: Micro silencing | PDF (106 KB)
p741 | doi:10.1038/nrc2513
Genetics: More than one way.... | PDF (151 KB)
p742 | doi:10.1038/nrc2510
Reviews
Basal cell carcinomas: attack of the hedgehog
Ervin H. Epstein
p743 | doi:10.1038/nrc2503
The discovery that aberrant Hedgehog signalling can lead to the development of basal cell carcinoma (BCC) has facilitated a remarkable increase in our understanding of BCC. How is this information being used to refine the treatment of this disease?
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Jane E. Visvader & Geoffrey J. Lindeman
p755 | doi:10.1038/nrc2499
In this Review article, the authors discuss the evidence supporting the existence of CSCs in solid tumours.
See also: | Correspondence by Olivier Gires et.al | Correspondence by Geoffrey J. Lindeman et.al |
Article series: RB and E2F
The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
Kay F. Macleod
p769 | doi:10.1038/nrc2504
This Review assesses emerging data that indicate a specific role for the RB tumour suppressor pathway in the response of the haematopoietic system to oxidative stress, and discusses the relevance of these findings to future cancer therapies.
The TRAIL apoptotic pathway in cancer onset, progression and therapy
Ricky W. Johnstone, Ailsa J. Frew & Mark J. Smyth
p782 | doi:10.1038/nrc2465
Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy: both recombinant TRAIL and monoclonal antibodies that target these receptors have entered clinical trials. How are these agents faring? What are the current stumbling blocks?
Perspectives
Opinion
Replication licensing and cancer — a fatal entanglement?
J. Julian Blow & Peter J. Gillespie
p799 | doi:10.1038/nrc2500
Replication licensing proteins are inappropriately expressed and misregulated in a wide variety of cancers. What are the consequences for DNA replication and genomic stability?
Opinion
Bone morphogenetic protein signalling in colorectal cancer
James C. Hardwick, Liudmila L. Kodach, G. Johan Offerhaus & Gijs R. van den Brink
p806 | doi:10.1038/nrc2467
Mutations in the bone morphogenetic protein pathway have been found in juvenile polyposis, an inherited polyposis syndrome that predisposes to colorectal cancer. What relevance do these findings have to sporadic cases of colorectal cancer?
Opinion
Can genes for mammographic density inform cancer aetiology?
Linda E. Kelemen, Thomas A. Sellers & Celine M. Vachon
p812 | doi:10.1038/nrc2466
High mammographic density (MD) is an established risk factor for breast cancer. In theory, the number of genes that regulate MD should be smaller than that influencing breast cancer risk. How informative have the initial studies of the genetics of MD proved to be?
Correspondence
Correspondence: Opinions regarding cord blood use need an update
J. J. Nietfeld
p823 | doi:10.1038/nrc2418-c1
Correspondence: Cord blood stem cells: worth the investment
David T. Harris
p823 | doi:10.1038/nrc2418-c2
Correspondence: Towards a hybrid model for the cryopreservation of umbilical cord blood stem cells
Zafiris Polymenidis & George P. Patrinos
p823 | doi:10.1038/nrc2418-c4
