Perspective
Nature Reviews Cancer 8, 976-990 (December 2008) | doi:10.1038/nrc2231
Article series: MYC
Timeline: Reflecting on 25 years with MYC
Natalie Meyer1 & Linda Z. Penn2 About the authors
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Abstract
Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is astonishing how each incremental insight into MYC regulation and function has also had an impact on numerous biological disciplines, including our understanding of molecular oncogenesis in general. Here we chronicle the major advances in our understanding of MYC biology, and peer into the future of MYC research.
Author affiliations
- Natalie Meyer is at Amgen Canada, Inc. Mississauga, Ontario, L5N 7Y2, Canada.
- Linda Z. Penn is at the Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, 610 University Avenue, Room 9-628, Toronto, Ontario M5G 2M9, Canada.
Correspondence to: Linda Z. Penn2 Email: lpenn@uhnresearch.ca
