Genetics: An unanticipated role | PDF (257 KB)

p765 | doi:10.1038/nrc2749

Genetics: Becoming mobile | PDF (195 KB)

p766 | doi:10.1038/nrc2750

MicroRNA: Stage-specific signatures | PDF (172 KB)

p766 | doi:10.1038/nrc2752

Therapeutic resistance: Smoothing the way | PDF (193 KB)

p768 | doi:10.1038/nrc2751

Cancer stem cells: Symmetry is key | PDF (136 KB)

p768 | doi:10.1038/nrc2757

Hypoxia: HIF1 in opposition | PDF (223 KB)

p769 | doi:10.1038/nrc2755

Therapy: Swings and roundabouts | PDF (221 KB)

p770 | doi:10.1038/nrc2754

Genomics: We are individuals | PDF (157 KB)

p770 | doi:10.1038/nrc2756

Nanotechnology: Take a deep breath | PDF (124 KB)

p771 | doi:10.1038/nrc2753

Polycomb group proteins: navigators of lineage pathways led astray in cancer

Adrian P. Bracken & Kristian Helin

p773 | doi:10.1038/nrc2736

The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation and are often deregulated in cancer. How might they become deregulated and how does this contribute to tumorigenesis?

• Abstract
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Emerging roles of E2Fs in cancer: an exit from cell cycle control

Hui-Zi Chen, Shih-Yin Tsai & Gustavo Leone

p785 | doi:10.1038/nrc2696

The E2F transcription factors function in cell cycle control and are intimately regulated by RB. However, some tumours have concurrent RB1 inactivation and E2F overexpression. Are there alternative tumour-promoting activities for the E2F family that are independent of cell cycle regulation?

• Abstract
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• Supplementary information

STATs in cancer inflammation and immunity: a leading role for STAT3

Hua Yu, Drew Pardoll & Richard Jove

p798 | doi:10.1038/nrc2734

Signal transducer and activator of transcription (STAT) proteins help determine whether immune responses promote or inhibit tumours. Specifically, STAT3 increases tumour cell proliferation, survival and invasion and activates tumour-promoting inflammation, but also suppresses anti-tumour immune responses. STAT3 is therefore a promising target for cancer therapy.

• Abstract
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NFAT proteins: emerging roles in cancer progression

Maria Mancini & Alex Toker

p810 | doi:10.1038/nrc2735

Although the nuclear factor of activated T cells (NFAT) transcription factors have been studied predominantly in the immune system, they are expressed in all tissues. This Review discusses the emerging roles of NFATs in cells that comprise the tumour and tumour microenvironment, and how this pathway might be targeted therapeutically.

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