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Genetically engineered mouse models of cancer have taught us much about how cancer develops. However, as our understanding of the complexity of tumour biology has increased, the limitations of using mice to model human cancer have become evident. How can we improve genetically engineered mouse models of cancer so that they are more relevant to the conundrums that we are now trying to resolve?
This Poster, authored by Kristopher K. Frese and David A. Tuveson, provides an overview of how genetically engineered mice (GEM) have been developed to meet the changing needs of cancer researchers, and how humanising GEM, alongside the insightful use of current genetic technology, should ensure a continued role for mouse models in the bench to bedside continuum. This poster is freely available online thanks to support from the Cancer Research UK Cambridge Research Institute.
