Therapeutic resistance
Beginning in the July 2009 issue, Nature Reviews Cancer will be publishing a series of articles that take a look at different aspects of therapeutic resistance. Resistance to therapy — chemotherapy or radiotherapy — is an increasing problem in the care of patients with cancer. Numerous culprits have been identified, including environmental adaptations to therapy, aberrant regulation of drug transporters and signalling feedback loops that bypass targeted therapies. As discussed in the articles in this series, multi–targeted drugs, improved understanding of feedback regulation, pathway crosstalk and resistance mechanisms, as well as predictors of response all aim to overcome this significant challenge.
2009
September 2009 Vol 9 No 9
Biological determinants of endocrine resistance in breast cancer
Elizabeth A. Musgrove & Robert L. Sutherland
doi:10.1038/nrc2713
September 2009 Vol 9 No 9
Environment–mediated drug resistance: a major contributor to minimal residual disease
Mark B. Meads, Robert A. Gatenby & William S. Dalton
doi:10.1038/nrc2714
August 2009 Vol 9 No 8
CYP2D6 and tamoxifen: DNA matters in breast cancer
Janelle M. Hoskins, Lisa A. Carey & Howard L. McLeod
doi:10.1038/nrc2683
July 2009 Vol 9 No 7
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
José Baselga & Sandra M. Swain
doi:10.1038/nrc2656
