Nature Reviews Drug Discovery
Volume 7, No 12 December 2008
Main pages for finding content:
2007 ISI Impact Factor 23.308(*Source of Impact Factor data)
Current issue
News
End of the line for cannabinoid receptor 1 as an anti–obesity target?
Dan Jones
A wave of terminations of development programmes for cannabinoid receptor 1 blockers for obesity indicates the demise of a drug class that was once anticipated to yield blockbusters. Nevertheless, lessons learned might help salvage something for future such approaches.
Current issue
News feature
Anticipating REMS
Bethan Hughes
The US FDA can now require companies to develop a risk evaluation and mitigation strategy (REMS) for therapeutic products. Bethan Hughes investigates the recent evolution of risk-management strategies in drug development.
Current issue
Review
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim, Wenjie Xu & John C. Reed
Reed and colleagues discuss the role of cell death pathways initiated by endoplasmic reticulum stress in diseases including neurodegeneration, hypoxia, heart disease, diabetes and immune disorders, and highlight promising therapeutic targets.
Current issue
Research Highlights
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Protein–protein Interactions:
Getting rid of JNK
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Type 1 diabetes:
Islet renovation
Current issue
Review
Directing cancer cells to self–destruct with pro-apoptotic receptor agonists
Avi Ashkenazi
Pro–apoptotic receptor agonists can selectively induce apoptosis in a wide spectrum of malignant cells. Ashkenazi discusses the scientific rationale, emerging clinical data and future potential for this new class of anticancer drugs.
Current issue
Review
Double–edged swords as cancer therapeutics: simultaneously targeting p53 and NF–κB pathways
Anwesha Dey, Vinay Tergaonkar & David P. Lane
Apoptosis can be induced by activating/stabilizing p53, and by inhibiting NF–κB. This article discusses the properties of compounds that possess both properties, and provides an outlook to their development as anticancer drugs.
Noticeboard
Focus on Pain
Unrelieved pain associated with conditions such as arthritis, diabetes, cancer and serious injury represents a major unmet medical need. With the aim of highlighting approaches to tackling the challenges in this field, this special collection integrates articles that discuss strategies to drive forward analgesic drug development with those that explore new targets for pain therapeutics.
Produced with support from Eli Lilly and Company, which had no control over its content.
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Focus on Antivirals
This joint Web Focus from Nature Reviews Drug Discovery and Nature Biotechnology hosts a collection of reviews, research highlights and commentaries covering the science and business of antiviral drug R&D. Thanks to the generous support of Pfizer (principal sponsor) and Gilead (supporting sponsor), content in the focus is freely available until June 2008.
PSI–Nature Structural Genomics Knowledgebase
A new window onto the world of protein structure has opened with the free PSI–Nature Structural Genomics Knowledgebase (PSI–SGKB). The site makes available the research data and tools from the Protein Structure Initiative, complemented with structural biology updates from NPG. Users can also suggest proteins for structure analysis.
Conferences
A selection of conferences in the field of drug discovery and development.
NPG BioPartnering site
This site is dedicated to small and large companies looking for commercial partnerships and finding out more about licensing.
Nature Reports Stem Cells
Nature Reports Stem Cells for the latest news, research, comment and analysis about stem cells and their implications.
Career snapshots
Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field.
Naturejobs spotlights and regions
Interactive regional map linking to information, features and career opportunities worldwide.
Natureevents
A comprehensive resource of information on scientific events and conferences around the world.
Journal Citation Reports, Thomson, 2007
