Current Issue

Featured article

Diagnosis of insulinoma in a patient with hypoglycemia without obvious hyperinsulinemia

Catarina Coelho, Maralyn R. Druce & Ashley B. Grossman

Initial diagnosis of insulinoma requires demonstration of inappropriately elevated insulin levels and concurrent hypoglycemia in the absence of administration of exogenous insulin or sulphonylureas. This article presents the case of a patient with insulinoma, who presented with hypoglycemia without coinciding evident hyperinsulinemia according to current guidelines. The article details current diagnostic criteria and highlights the role of clinical judgment in the investigation and management of cases, which do not conform to an expected pattern.

Current Issue

Featured article

Thyroid gland: Pregnancy—a risk factor for thyroid surgery complications

Daniel Ruan & Jacob Moalem

Pregnancy can exacerbate endocrinopathies and obscure their diagnosis in patients with parathyroid or thyroid disease. A large, population-based study published in Archives of Surgery demonstrates that pregnant women carry an increased risk of surgical complications, longer hospitalization and higher costs from parathyroid and thyroid surgery than nonpregnant patients.

Current Issue

Also in this issue

Review: Nutritional programming of the metabolic syndrome

Review: Management of children with acute malnutrition in resource-poor settings

Perspective: Opinion: CB1 antagonists for obesity—what lessons have we learned from rimonabant?

Current Issue

Research Highlights

Bone: Vitamin D deficiency implicated in bone mineralization defects

Diabetes: Antipsychotic drugs and hyperglycemia risk in diabetes

Pituitary gland: Prevalence of pituitary adenomas in a geographically well-defined population