Nature Reviews Genetics
Volume 10, No 11 November 2009
Also this month
Article series: Fundamental concepts in genetics
Featured Article
Spatial patterns of variation due to natural selection in humans
John Novembre & Anna Di Rienzo
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Review
Article series: Modelling
Synthetic biology: understanding biological design from synthetic circuits
Shankar Mukherji & Alexander van Oudenaarden
The article highlights how the process of engineering biological systems has contributed to our understanding of how endogenous systems are put together and function — from a quantitative description of gene expression and signal transduction to controlling spatial organization and cell–cell interactions.
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Review
Generating specificity and diversity in the transcriptional response to hypoxia
Urban Lendahl, Kian Leong Lee, Henry Yang & Lorenz Poellinger
In addition to the core hypoxic transcriptional pathway, several mechanisms exist to allow transcriptional diversity and specificity. This Review highlights recent advances in our understanding of the mechanisms and factors that contribute to the tailoring of the appropriate hypoxic transcriptional response.
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Opinion
Article series: Genome–wide association studies
Common disorders are quantitative traits
Robert Plomin, Claire M. A. Haworth & Oliver S. P. Davis
Results from genome–wide association studies support the view that qualitative disorders can be interpreted as being the extremes of quantitative dimensions. Research on quantitative traits could have far–reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
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Viewpoint
Induced pluripotent stem cells and reprogramming: seeing the science through the hype
Juan Carlos Izpisúa Belmonte, James Ellis, Konrad Hochedlinger & Shinya Yamanaka
Four leading researchers contribute their personal opinions on recent progress and current challenges in induced pluripotent stem cell research. Their varied perspectives suggest that for clinical applications there is cause for optimism, tempered with caution, and they highlight exciting recent advances in reprogramming and differentiation.
CURRENT ISSUE
Poster
The pervasive and interleaved transcriptome
Thomas R. Gingeras
Using snapshots at different levels of resolution — from chromosomes down to a few nucleotides — this poster provides a window into the layers of complexity of eukaryotic transcriptomes and introduces novel transcriptional phenomena and types of RNA.
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Research Highlights
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Gene expression:
Regulators hidden in human proteome
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Evolution:
The routes of adaptation
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Development:
Size control by divide and rule
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Sex determination:
The means to discriminate
More Genetics
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Recommended Links
Links recommended by the Editors
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Web Focus Collection
Selected articles from the Nature Publishing Group on key current topics
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Article Series
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Genetics Conferences
A calendar of forthcoming meetings and workshops from across the field of genetics and genomics.
Noticeboard
Nature Reviews Genetics is now on Twitter. Follow us to keep up–to–date with the latest content.
Web Collection on Influenza
Influenza pandemics occur with some frequency, as indicated by the recent outbreak of swine flu (influenza A (H1N1)). Learn more about influenza, previous 'flu pandemics, preventative measures against 'flu and how the spread of disease can be modelled and possibly predicted with these selected Nature Reviews Microbiology and Nature Reviews Genetics articles.
Supplement on genomic medicine in developing countries
This collection of Perspective articles describes human genome variation studies taking place in Mexico, India, Thailand, and South Africa. It discusses the challenges and opportunities facing these and other developing countries in harnessing genomics for the benefit of their populations.
Milestones in DNA technologies
Nature Methods, Nature Reviews Genetics and Nature are proud to present The Nature Milestones in DNA technologies, a series of articles and commentaries highlighting the most influential developments in DNA–related techniques over the past half–century.
Visit the Milestones website made freely accessible thanks to the support of QIAGEN.
Web focuses
A Web Focus is a selection of articles on a related theme drawn from the entire Nature Publishing Group family of journals. With content ranging from Research Highlights, Reviews and Perspectives through to primary research papers, a Web Focus provides a panoramic view of a key area of biology.
RNAi animation
Nature Reviews Genetics and Arkitek present an animation of the RNAi process. Click here for access to the accompanying RNAi Web Focus, which includes relevant content from across Nature Publishing Group.
Statistical genetics audio supplement
How will advances in statistics aid genetic analyses? Find out what the experts think in our Focus audio supplement: 'Genetics by numbers'
Nature Omics gateway
The Nature Omics gateway is a comprehensive compilation of large-scale genomic biology content, drawn from the complete range of Nature Publishing Group publications. Content includes research and review articles, news, commentaries and research highlights.
2008 Journal Citation Report (Thomson Reuters, 2009)
