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Three papers in Nature identify ZBP1 as a key effector of cell death and inflammation downstream of ADAR mutation, as occurs in patients with Aicardi-Goutières syndrome.
IL-17 production by skin-resident γδ T cells is required for optimal HIF1α activation in damaged epithelium, leading to epithelial cell migration and re-epithelialization.
Medullary thymic epithelial cells co-opt lineage-defining transcription factors to mimic numerous peripheral cell types and express their antigens against which maturing T cells can be tolerized.
As part of our Women in Immunology series, this article pays tribute to Lydia Rabinowitsch-Kempner, who is remembered not only for her work on tuberculosis and public health but also as an advocate for women’s rights.
A newly identified pregnancy-specific deacetylation of maternal antibodies expands their ability to vertically transmit protection against intracellular infection in neonates.
The amino acid leucine promotes an immunosuppressive population of B cells, and dietary restriction of leucine could benefit patients with colorectal cancer.
Lymph node colonization by tumour cells promotes subsequent spread to distant tissues by inducing broad alterations in tumour immunity and generating tumour-specific immune tolerance.
FlipFlop mice, in which the coreceptor proteins encoded by the Cd4 and Cd8 loci are reversed, shed light on the importance of T cell receptor signal length versus signal strength in determining helper versus cytotoxic T cell lineage fates.
A newly described subset of innate-like lymphocytes with cytotoxic capabilities is shown to have an important role in cancer immunosurveillance. This cell population is broadly self-reactive, has a unique ontogeny and gains cytotoxic potential on sensing IL-15 in tumours.
Clusters of quiescent cancer cells in triple-negative breast cancer create an immunosuppressive microenvironment that might contribute to immunotherapy resistance and tumour recurrence.
B cells signal to bone marrow niche cells via the neurotransmitter acetylcholine, curtailing immune cell production in the steady state and limiting the supply of inflammatory myeloid cells in cardiovascular disease.
Two papers in Science Immunology describe a role for tuft cells in the gallbladder and bile ducts in sensing bacteria and their products ascending from the small intestine to stimulate antibacterial immune responses.
A bispecific molecule consisting of a PD1 antibody fused to a multimeric ligand for the costimulatory molecule GITR shows promising results in preclinical studies of solid tumours.
Steady-state sensing of Skint1 on keratinocytes by the γδ T cell receptor on dendritic epidermal T cells (DETCs) maintains DETCs in a poised state ready to respond to subsequent distress signals and restore epithelial homeostasis.
The accumulation of misfolded or otherwise unwanted proteins in a cell, known as proteotoxic stress, triggers an inflammatory response. This study describes a role for PKR as the sensor of protein accumulation, which triggers an innate immune response and helps to restore homeostasis.
