Research Highlights in 2022

The serotonin metabolite 5-HIAA is a potent ligand for GPR35 and promotes neutrophil recruitment to inflamed sites.

A longitudinal study of CAR T cells from patients successfully treated for chronic lymphocytic leukaemia in 2010 provides fascinating insights into CAR T cell features that allow for long-term control of disease.

T cells need magnesium to function efficiently. They sense it via the cell surface integrin LFA-1, which triggers outside-in signalling to augment T cell effector functions against infection or cancers.

Emerging evidence supports the idea that Epstein-Barr virus can drive the development of multiple sclerosis, potentially through molecular mimicry.

Intestinal ILC3s produce the epidermal growth factor family mediator HB-EGF, which protects the intestinal barrier against TNF-induced epithelial cell death.

The transcription factor NFAT acts as a checkpoint in activated platelets to control their aggregation and interaction with neutrophils, keeping thrombotic and inflammatory responses in check.

Less than a month after the sequence of the SARS-CoV-2 Omicron variant was first announced, a number of articles in Nature and Cell examine its immune evasion characteristics.

Loss of oscillatory expression of KLF4 in aged macrophages disrupts circadian immune functions and increases susceptibility to bacterial infections.