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A study in Nature Biotechnology investigated context-specific host–microorganisms interactions by using spatial transcriptomics to profile gene expression of host and microbial genes simultaneously.
Inhibition of adrenergic receptors following a traumatic brain injury reduces cerebral oedema and inflammation by restoring fluid efflux through the glymphatic and lymphatic systems.
A new mouse model of sleep deprivation reveals a potent pathway by which sleep-related changes in prostaglandin D2 in the central nervous system can affect the peripheral immune system.
Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future pregnancy complications.
A new study shows that even a short-term switch to a low-fibre diet suppresses immunity to bacterial infection and compromises effector T cell responses.
A study in Nature reports a lactate–HIF1α–NDUFA4L2 pathway in intestinal dendritic cells that regulates the inflammatory priming of encephalitogenic T cells.
Two studies in Nature describe the mechanisms that underlie allergen avoidance behaviour in mice, linking allergen sensing in the gut to a protective behavioural response to repeated ingestion of allergen.
A study in Immunity reports that a high-fat diet in mice leads to the loss of PPARγ+ Treg cells in the skin, which exacerbates psoriasis mediated by IL-17-producing γδ T cells.
Individuals with the HLA-B*15:01 allele may have pre-existing T cells derived from seasonal coronavirus infections that cross-protect against SARS-CoV-2.
In contrast to its role in promoting immune responses to viral and bacterial infections, STING inhibits SYK-dependent cytokine production in response to fungal infection.