Nature Reviews Immunology
Volume 9, No 7 July 2009
Featured Article
New insights into the regulation of T cells by γc family cytokines
Yrina Rochman, Rosanne Spolski & Warren J. Leonard
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2008 ISI Impact Factor 30.01(*Source of Impact Factor data)
Advance online publication
Review
A cell biological view of Toll–like receptor function: regulation through compartmentalization
Gregory M. Barton & Jonathan C. Kagan
The activation and signalling pathways engaged by Toll–like receptors (TLRs) are determined by their localization in the cell. Here, the authors explain how generic cellular machinery involved in the compartmentalization of receptors and signalling molecules contributes to TLR function and regulation.
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Advance online publication
Review
Membrane vesicles as conveyors of immune responses
Clotilde Théry, Matias Ostrowski & Elodie Segura
Exosomes can act as messengers, carrying biological information between cells. Here, the authors describe the numerous effects that exosomes have on immune cells and discuss how they might be harnessed to promote or limit immune responses for therapeutic purposes.
CURRENT ISSUE
Perspective
Towards the identification of biomarkers of transplantation tolerance
Laurence A. Turka & Robert I. Lechler
The identification of biomarkers of transplantation tolerance holds promise to improve the care of transplant recipients and advance our understanding of alloreactive immune responses. What progress has been made towards reaching this goal and what challenges remain?
CURRENT ISSUE
Review
Signalling through C–type lectin receptors: shaping immune responses
Teunis B. H. Geijtenbeek & Sonja I. Gringhuis
Here, Teunis Geijtenbeek and Sonja Gringhuis discuss the role of the signalling pathways induced by C–type lectin receptors in determining T helper cell lineage commitment and describe how these pathways can be exploited for the development of new vaccination strategies.
CURRENT ISSUE
Research Highlights
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Evolution:
A common solution to an age–old problem
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T cell memory:
Keeping energy levels up
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T cell differentiation:
Inhibiting TH17 cells
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Signaling Gateway
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Cell Migration Gateway
The definitive online resource for all the latest developments in cell migration
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Immunology Conferences
A calendar of forthcoming meetings and workshops from across the field of immunology.
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Nature Reports Avian Flu
The latest research news, comments and analysis on avian flu
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Recommended Links
Links recommended by the editors
Noticeboard
Focus on neuroimmunology
Understanding the crosstalk between the nervous and immune systems and how it can be dysregulated provides us with crucial insights necessary for the treatment of neurological diseases such as multiple sclerosis and Alzheimer's disease. Nature Reviews Immunology presents a special Focus issue featuring articles that review our current understanding of the immunopathogenesis of and emergent immunotherapies for these neurological diseases.
Poster on Type I interferon and SLE
The study of Systemic Lupus Erythematosus (SLE) patients has revealed a central role for IFN–α in disease pathogenesis. This poster provides an overview of how IFN signaling is intimately involved in SLE pathogenesis. The poster is available thanks to support from PBL InterferonSource.
Poster on Antigen processing and presentation
This poster provides an updated overview of the intracellular pathways and mechanisms by which antigens are captured, processed and loaded onto MHC class I, class II and CD1d molecules for presentation to T cells. The poster is freely available thanks to support from StemCell Technologies.
Focus on Immune Signaling Cross–talk
Nature Immunology presents a focus on the complex interplay among signaling pathways operative in immune cells. The focus contains a specially commissioned overview, three review articles and two perspectives. Also included are highlights of recent research findings and several short comments–written by experts—providing in–depth insight into specific signal cross–talk points.
Focus on CD4+ T–cell diversity
CD4+ T cells have a crucial role in orchestrating immune responses, as well as in immune regulation. The recent identification of IL–17–expressing T cells (TH17 cells) has raised fundamental questions about lineage commitment and fate determination of CD4+ T cells. This Focus describes the molecular pathways that govern the differentiation of TH1, TH2, TH17 and regulatory T cells.
Article series on Tissue–specific immune responses
In October 2008, Nature Reviews Immunology begin a series of articles related to tissue–specific immune responses. These articles will consider aspects of immune responses in the context of the tissue in which they occur and highlight how tissue cells or tissue–derived factors in different organs can shape the outcome of these responses.
Structural Genomics Knowledgebase
A new window onto the world of protein structure has opened with the new, free PSI–Nature Structural Genomics Knowledgebase (PSI–SGKB). The site makes available the research data and tools from the Protein Structure Initiative, complemented with structural biology updates from NPG. Users can also suggest proteins for structure analysis.
Focus on Dendritic Cells
This Focus from Immunology & Cell Biology presents a collection of review and research articles that outline our current understanding of DC heterogeneity, how different populations contribute to T–cell responses, and how T cells differentiate and maintain functional diversity.
Focus on Leukocyte Trafficking
This Focus from Nature Immunology presents five specially commissioned reviews and an overview that discuss how immune cells traffic through tissues and lymphoid organs.
Nature Reviews Genetics Wiki
Nature Reviews Genetics presents a first for Nature Publishing Group — a Review that can be commented on, updated, and added to by readers using Wiki features. The Review explores the past, present and future of the biology cyberinfrastructure.
Focus on Mucosal Immunology
This Focus from Nature Reviews Immunology highlights the latest advances in our understanding of host–microbe interactions at mucosal sites and the consequences of immune dysregulation at these sites.
Focus on Natural Killer Cells
Nature Immunology presents a series of specially commissioned articles that focus on the differentiation, responsiveness and biological roles of natural killer cells. The focus is available free to registrants for 6 months.
Focus on Allergy and Asthma
Millions of people worldwide suffer from respiratory diseases such as allergies, asthma and chronic obstructive pulmonary disease, and these diseases constitute a major public health burden. This Focus issue highlights the latest advances in our understanding of the immune bases of these diseases and outlines how this knowledge can be translated into more effective treatment strategies.
Poster on innate immunity: sensing and signalling
This poster provides an overview of the components and networks involved in pathogen sensing and signalling in the innate immune system. The poster is freely available thanks to support from MedImmune.
Web Focuses
Please visit our Web Focuses, which provide a selection of articles on a related theme drawn from Nature Publishing Group on key current topics of immunology.
Posters
Our Posters provide a visual overview of a hot topic in immunology. Thanks to generous support, they are freely available and can be viewed online as a high–resolution PDF.
Journal Citation Reports, Thomson, 2008
