Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Navdeep Chandel highlights a study published in 1996 that — by showing that mitochondria can release cytochromecto initiate apoptosis — changed his view of the role of mitochondria in physiology.
Christopher Chen highlights the early studies of mechanoregulation of cell–matrix adhesions that established mechanobiology as a cross-discplinary research field
Daniel Gerlich discusses how a study by the Hyman laboratory introduced the theory of liquid phase separation to cell biology and its implications for the understanding of cell organization and function.
A modification of Meselson and Stahl's density gradient centrifugation method and a rare Texan yeast helped show that eukaryotic ribosomes dissociate and reform during translation.
Thomas D. Pollard discusses the early work of Thompson and Wolpert on cytoplasmic extract from amoebae, which laid the foundation for studies of actin-driven cell motility.
Allan Jacobson reminds us of how a study by Deveret al. published in 1992 connected several data on translational regulation, bringing attention to its crucial role in the regulation of gene expression.
Kai Simons discusses how MDCK cells grown on semi-permeable filters have become a model for studying apico-basal cell polarity with the use of viruses.
