Cell signalling: A new MAP for miRNAs | PDF (162 KB)

p734 | doi:10.1038/nrm2792

Autophagy: Autophagy takes an alternative route | PDF (139 KB)

p735 | doi:10.1038/nrm2790

mRNA decay: Removing the tail | PDF (162 KB)

p736 | doi:10.1038/nrm2781

Chromatin: JAK2 goes nuclear | PDF (107 KB)

p736 | doi:10.1038/nrm2783

Chromosome biology: Small RNAs find the centre | PDF (176 KB)

p738 | doi:10.1038/nrm2791

Stem cells: iPS cells strike a cord | PDF (129 KB)

p738 | doi:10.1038/nrm2794

Apoptosis: Watching caspase 2 get active | PDF (143 KB)

p739 | doi:10.1038/nrm2788

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Mo Chen & James L. Manley

p741 | doi:10.1038/nrm2777

Alternative splicing is an important gene regulatory mechanism for generating proteomic diversity, which markedly affects human development and is misregulated in many human diseases. Alternative splicing can be regulated at different stages of spliceosome assembly and by different mechanisms.

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Building ubiquitin chains: E2 enzymes at work

Yihong Ye & Michael Rape

p755 | doi:10.1038/nrm2780

Ubiquitin-conjugating enzymes (E2s) are major regulators of ubiquitin chain assembly. These enzymes control ubiquitin chain initiation or elongation, the processivity of chain formation and the topology of the assembled chains.

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• Supplementary information

Traffic control: regulation of kinesin motors

Kristen J. Verhey & Jennetta W. Hammond

p765 | doi:10.1038/nrm2782

How kinesin motors are regulated in cells to ensure the temporal and spatial fidelity of their microtubule-based activities is poorly understood. Recent work has revealed molecular mechanisms that control kinesin autoinhibition, activation, binding to cargos and microtubule tracks, and localization.

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Non-muscle myosin II takes centre stage in cell adhesion and migration

Miguel Vicente-Manzanares, Xuefei Ma, Robert S. Adelstein & Alan Rick Horwitz

p778 | doi:10.1038/nrm2786

Non-muscle myosin II (NM II) is an actin-binding protein with actin cross-linking and contractile properties. The three mammalian NM II isoforms have both overlapping and distinct roles in cell adhesion and cell migration and their mutation results in specific developmental defects and disease phenotypes.

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Evolution of biomolecular networks — lessons from metabolic and protein interactions

Takuji Yamada & Peer Bork

p791 | doi:10.1038/nrm2787

The evolution of protein–protein interaction and metabolic networks is mostly based on the duplication and loss of entire genes or on point mutations, small insertions or deletions that affect gene regulation. However, network evolution can be understood only when spatiotemporal resolution is taken into account.

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