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In response to tissue damage in adults, embryonic gene expression programmes are reactivated to enhance repair. Hassan Fazilaty describes a correlation between damage extent and how early in embryogenesis the restored expression programme is.
In this Tools of the Trade article, Laura Capolupo (at D’Angelo lab) describes the approach to study cell-to-cell heterogeneity in lipid content and its correspondence to cell identity.
In this Tools of the Trade article, Benjamin Jackson (at the Finley lab) describes the use of genetic co-essentiality analysis to interrogate the assembly of metabolic networks, fuelling discovery of new aspects of metabolism.
The eukaryotic genome is organized into topologically associating domains by cohesin and CTCF. Davidson et al. now reveal a role for DNA tension in the regulation of the CTCF–cohesin interaction to modulate domain boundaries.
Cold temperature prolongs lifespan in nematodes by inducing ubiquitin-independent proteasome activity, which prevents protein aggregation and neuronal degeneration. The pathway is conserved in humans.
The genome contains various non-coding regulatory elements, including silencers of gene expression. Recent progress in the identification and characterization of silencers has considerably deepened our understanding of their function, and has shed light on the potential relevance of targeting silencers in therapy for hereditary diseases.
The inability of the mammalian central nervous system to functionally regenerate after injury is largely attributable to the limited capacity of injured neurons to regrow axons. In the spinal cord, recent work on the mechanisms restricting axon regrowth suggests new therapeutic avenues to promote functional recovery after damage.
Ribosome biogenesis, including ribosomal RNA (rRNA) production, occurs in the nucleolus. Recent studies have revealed how the integrity and copy number of rRNA genes is maintained through a unique recombination system, how rRNA transcription is regulated and how phase separation orchestrates nucleolus function.
This Consensus Statement addresses the definition, nomenclature and classification of long non-coding RNAs, and provides a shared viewpoint on their features and functions. The authors also discuss research challenges and provide recommendations to advance our understanding of long non-coding RNAs.
