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In this Tools of the Trade article, Yohan Lee (Stachowiak lab) describes a method to generate free-standing planar lipid membranes for the study of membrane-associated protein phase separation.
In this Tools of the Trade article, Lei Yuan (from the Cai lab) highlights a new culture system that allows in vitro reconstitution of a dynamic miniature mammary gland.
In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted our understanding of the functionality of transcription factors.
Adherens junctions (AJs) are canonical mediators of cell–cell adhesion that support embryonic development and tissue homeostasis. This Review discusses how the properties and behaviours of embryonic tissues emerge from the collective molecular interactions that occur at AJs.
White adipose tissue serves a plethora of physiological functions, which are compromised in obesity. The mechanisms through which obese white adipose tissue contributes to pathologies including insulin resistance, dyslipidaemia, chronic inflammation, cancer and decreased fertility are emerging. In the future, these insights can be translated into novel drugs for obesity and obesity-associated diseases.
The Rho GTPases are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and morphogenesis by promoting cytoskeleton-based changes in the cell cortex. These different functions are driven by the ability of Rho GTPases to self-organize, forming diverse spatiotemporal cortical patterns.
ATP-dependent chromatin remodellers regulate chromatin transactions — transcription, replication and DNA repair — by re-arranging nucleosomes. Recent studies have elucidated the organization of remodeller complexes, their ATPase activity, their regulation and their pathological dysregulation.
