Bacterial physiology: Mirror signal, manoeuvre | PDF (445 KB)

p759 | doi:10.1038/nrmicro2250

Fungal physiology: Stressed fungi are not highly sprung | PDF (507 KB)

p760 | doi:10.1038/nrmicro2247

Bacterial pathogenesis: A 'hijacked' regulatory mechanism | PDF (215 KB)

p760 | doi:10.1038/nrmicro2252

Symbiosis: A partnership cast in iron | PDF (220 KB)

p760 | doi:10.1038/nrmicro2255

Bacterial immune evasion: An evasive surface | PDF (293 KB)

p762 | doi:10.1038/nrmicro2251

Fungal physiology: Candida puts RNA at the tip | PDF (182 KB)

p762 | doi:10.1038/nrmicro2254

Structural biology of the chaperone–usher pathway of pilus biogenesis

Gabriel Waksman & Scott J. Hultgren

p765 | doi:10.1038/nrmicro2220

Chaperone–usher pili are assembled and secreted by a periplasmic chaperone and a dimeric outer-membrane usher complex. Gabriel Waksman and Scott Hultgren review the structural information that has been gathered over the past decade on the various players that participate in P and type 1 pilus biogenesis.

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The trypanosome flagellar pocket

Mark C. Field & Mark Carrington

p775 | doi:10.1038/nrmicro2221

The flagellar pocket of Trypanosoma brucei is a small invagination in the plasma membrane where the flagellum exits the cytoplasm. In this Review, Mark Field and Mark Carrington highlight the importance of this complex organelle for cell polarity, cell division, protein trafficking and immune evasion.

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The evolutionary conundrum of pathogen mimicry

Nels C. Elde & Harmit S. Malik

p787 | doi:10.1038/nrmicro2222

A diverse range of pathogens produce molecules that mimic host cell components to subvert host cell functions. Elde and Malik highlight the various types of mimicry used by pathogens and the measures that host cells use to counteract the mimics' effects.

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• Supplementary information

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

Mayte Coiras, María Rosa López-Huertas, Mayte Pérez-Olmeda & José Alcamí

p798 | doi:10.1038/nrmicro2223

Latent HIV-1 reservoirs, in which the viral genome becomes permanently integrated into the host chromosome, are established early during primary infection and pose a substantial obstacle to the eradication of HIV-1 infection. Here, José Alcamí and colleagues discuss the mechanisms that are associated with HIV-1 latency and outline strategies for targeting HIV-1 reservoirs.

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Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseases

Paul S. Keim & David M. Wagner

p813 | doi:10.1038/nrmicro2219

Infectious diseases emerge and spread around the globe. Using the distribution, establishment and spread of anthrax, plague and tularaemia as examples, Keim and Wagner describe the factors that determine the phylogeography of emerging diseases.

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