Nature Reviews Neuroscience
Volume 10, No 7 July 2009
Featured Article
Mitochondrial membrane permeabilization in neuronal injury
Lorenzo Galluzzi, Klas Blomgren & Guido Kroemer
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2008 ISI Impact Factor 25.94(*Source of Impact Factor data)
Advance online publication
Review
The glutamate homeostasis hypothesis of addiction
Peter W. Kalivas
In addiction, the prefrontal cortex fails to control drug–seeking behaviours. Peter Kalivas reviews the hypothesis that a loss of glutamate homeostasis at prefrontal–to–accumbens synapses, resulting in altered dendritic spine morphology and synaptic plasticity, impairs the prefrontal regulation of striatal circuitry.
Advance online publication
Opinion
Inside the brain of an elite athlete: the neural processes that support high achievement in sports
Kielan Yarrow, Peter Brown & John W. Krakauer
What sets highly skilled sportspeople apart from novices? This article discusses the neural basis of sporting skills and emerging computational and physiological theories that help explain, and potentially predict, elite athletic performance.
Current Issue
Review
Circuits controlling vertebrate locomotion: moving in a new direction
Martyn Goulding
Intrinsic spinal cord networks generate the rhythmic patterns of motor activity that underlie locomotion. Goulding shows how genetic analyses, coupled with classical systems neuroscience approaches, are providing new information about the cellular components and functional organization of these circuits.
Current Issue
Opinion
Principles of neural ensemble physiology underlying the operation of brain–machine interfaces
Miguel A. L. Nicolelis & Mikhail A. Lebedev
Recent advances in brain–machine interface technology have allowed neuroscientists to gain insights into the principles underlying information processing in the CNS. Nicolelis and Lebedev propose a series of principles of neural ensemble physiology that have arisen from this research.
Current Issue
Progress
New sites of action for GIRK and SK channels
Rafael Luján, James Maylie & John P. Adelman
GIRK and SK channels, two families of voltage–independent K+ channels, have recently been described at synaptic as well as extrasynaptic sites. Luján and colleagues discuss how associated signalling complexes in conjunction with local signals could result in the different functions of these two ion channel families.
Current Issue
Research Highlights
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Cerebellum:
An olive branch to two theories
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Development:
Terminal differentiation
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Sleep:
What goes up, must come down
More Neuroscience
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Recommended Links
Links recommended by the editors
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Neuropod
Neuroscience podcast from Nature, produced in association with the Dana Foundation.
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Web Focus Collection
Selected articles from the Nature Publishing Group
Noticeboard
Focus on Neuroimmunology
Understanding the crosstalk between the nervous and immune systems and how it can be dysregulated provides us with crucial insights necessary for the treatment of neurological diseases such as multiple sclerosis and Alzheimer's disease. Nature Reviews Immunology presents a special Focus issue featuring articles that review our current understanding of the immunopathogenesis of and emergent immunotherapies for these neurological diseases.
Focus on Stress
The body's response to stress has adaptive value, but exposure to chronic or severe stress — which is not uncommon in humans — can have long–lasting effects on brain structure and function, which can lead to changes in cognition and to disorders such as depression and post–traumatic stress disorder. This Focus issue highlights recent developments in this field, with a view to understanding the mechanisms that trigger and mediate stress responses, which will enable the development of therapeutic strategies aimed at treating stress–related disorders.
CNS precursors series
A series of articles highlighting recent advances in the identification of precursor cells and in our understanding of their regulation and functional roles.
Sleep series
A series of articles highlighting the genetic, cellular and systems basis of sleep and the importance of sleep for cognitive function and mental health.
Neuron–glia interactions series
A series of articles highlighting the interactions between different types of glia and neurons at the cellular and network levels.
Memory systems series
A special series of articles highlighting different types of memory and how they are represented in the brain.
Signalling in development series
A special series of articles highlighting recent progress in our understanding of the molecular mechanisms that are involved in all aspects of neural development.
Neuroimaging series
A special series of articles highlighting applications of neuroimaging techniques in all areas of neuroscience, including basic neurobiology, cognitive and behavioural neuroscience, translational neurology and clinical practice.
Journal Citation Reports, Thomson, 2009
