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As has been shown for developing excitatory synapses, microglia regulate connectivity in developing inhibitory circuits via a complement- and GABAB1 receptor-dependent mechanism.
A neural manifold analysis reveals that the hippocampus encodes both spatial and learned abstract information from the environment in a conjoined cognitive map.
In individuals with schizophrenia, a reduced capacity to infer relationships between visual stimuli is associated with impaired spontaneous neural replay.
Mammalian skin contains an array of specialized structures that transform mechanical forces into electrical signals. Handler and Ginty provide a comprehensive overview of the features of the skin’s mechanosensory end organs and the neurons with which they associate and consider how their diverse properties contribute to the sense of touch.
Many studies implicate a prefrontal–basal ganglia circuit in the control of action-stopping. Here, Ricci Hannah and Adam Aron provide an update of studies of this circuit, discuss its clinical relevance, and consider whether its action-stopping function applies in real-world scenarios, beyond the laboratory.
The brain is particularly susceptible to injury after ischaemia; however, emerging evidence suggests that, under certain conditions, it may show more resilience. Daniele et al. review the effects of ischaemia on the brain and efforts to study and protect the post-ischaemic brain.
How category-specific regions of cortex, or ‘domains’, in the primate ventral stream arise is unclear. In this Perspective, Arcaro and Livingstone present a ‘bottom-up’ model for the generation of these domains, whereby experience refines a domain-general architecture based on topographic maps of the sensory environment.
