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Featured article

Serum free light chain assessment in monoclonal gammopathy and kidney disease

Colin A. Hutchison, Kolitha Basnayake & Paul Cockwell

Abnormalities of immunoglobulin free light chains (FLCs) are frequently present in patients with monoclonal gammopathies and can cause kidney disease. In this article, Hutchison and colleagues review the biology of FLC production in health and disease, and the utility of FLC immunoassays in the assessment of monoclonal gammopathies in kidney disease.

Current Issue

Featured article

Time to rethink immunosuppression by mTOR inhibitors?

Marcus D. Säemann & Giuseppe Remuzzi

Several surprising findings indicate that pharmacological blocking of the multifunctional enzyme mTOR fosters distinct differentiation programs in different immunocompetent cells. These data might lead to a striking change in our view of the role that mTOR inhibition should have in immunosuppressive therapy for allogeneic transplant recipients.

KI Featured Article

Original Articles

Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease

Lowell J Lo, Alan S Go, Glenn M Chertow, Charles E McCulloch, Dongjie Fan, Juan D Ordoñez and Chi-yuan Hsu

Current Issue

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News and Views: Intradermal HBV vaccination is preferable in non-responders

Adeera Levin

Case study: Angiogenic factor abnormalities and fetal demise in a twin pregnancy

Hladunewich et al.

Review: Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury

Heemskerk et al.