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An anti-CD38 monoclonal antibody and an in vivo gene-editing approach show promise for the treatment of different forms of systemic amyloidosis in separate clinical trials.
New research shows that combination therapy for septic arthritis in mice considerably reduces intracellular bacteria in synovial tissue and protects against joint damage.
New research shows that platelets inhibit regulatory T cell immunosuppressive activity in systemic lupus erythematosus via P-selectin–PSGL1 interaction.
A new study describes an anti-inflammatory signalling pathway mediated by TNFR2 and the signalling molecule 14-3-3ε and the effects of this pathway on macrophage polarization.
An engineered protein that blocks CCR6–CCL20 signalling was able to prevent and treat skin, joint and entheseal inflammation in an IL-23-dependent mouse model of psoriatic arthritis.
Infection with malaria parasites can prevent progression to severe kidney disease in lupus-prone mice by preventing the migration of CCL17-producing dendritic cells to the kidneys.
In a new study, researchers have engineered exosomes that could be used to modulate the macrophage population in the synovium and promote resolution of arthritis.
A retrospective cohort study provides further insight into the 6-month outcomes of children with MIS-C, highlighting the importance of physical and mental rehabilitation.
Results of a new study implicate tenascin C in entheseal new bone formation in ankylosing spondylitis and suggest this protein could be targeted therapeutically.
The results of the AURORA 1 study show a superior effect on renal remission for voclosporin plus standard care over standard care alone in patients with lupus nephritis.
Targeting DNA methylation using a repurposed cancer drug reduces joint damage in mouse models of autoimmune arthritis by restoring the balance between T cell subsets.
A paper in JCI Insight reports a role for antibody glycosylation in the pathogenesis of lupus nephritis and suggests CaMK4 as a potential urinary biomarker of active disease.
Two new studies have identified mutations in UBA1 associated with the newly identified condition VEXAS syndrome in cohorts of patients with relapsing polychondritis, supporting the concept that relapsing polychondritis is more than one disease.
New research suggests that advanced inflammatory arthritis could be treated with a targeted chemotherapeutic strategy to selectively induce apoptosis in osteoclasts and inflammatory macrophages in affected joints.
Preclinical research suggests that inhibitors of PIM kinases currently in development in oncology could be repurposed for the treatment of early rheumatoid arthritis.
