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In screening for post-translational modifications associated with ankylosing spondylitis, researchers have identified a microbiome-metabolite-mediated modification that can lead to neoantigen generation and subsequent autoimmunity.
Characterization of a new mouse model highlights allogeneic bone marrow transplantation and granulocyte colony-stimulating factor neutralization as potential avenues for the treatment of APLAID.
New findings suggest that inhibition of macrophage fumarate hydratase leads to the release of mitochondrial RNA, which in turn mediates type I interferon production.
Following a fracture, γδ T cell expansion in the bone induces the expansion and migration of T helper 17 cells from the gut to the bone to help mediate fracture healing.
Anti-citrullinated protein antibodies precede the development of rheumatoid arthritis, but new results indicate that these antibodies are not necessarily pathogenic, and some might even protect against arthritis.
A comprehensive analysis has identified chromatin looping as the mechanism that underlies the association of a pleiotropic genetic variant with several autoimmune diseases.
Autoimmunity-associated recognition by IL-17A-expressing γδ T cells of high-mannose glycans expressed on kidney cells in patients with lupus nephritis can be mitigated in a mouse lupus model by dietary supplementation with N-acetylglucosamine.
The results of the two BRAVE phase III trials of baricitinib in the treatment of systemic lupus erythematosus were inconclusive, meaning that this clinical trial programme has now been terminated.
In a large cohort of patients with psoriasis, treatment with biologic DMARDs targeting the IL-23 pathway was associated with a reduced risk of developing inflammatory arthritis as compared with anti-TNF treatment.
Protein phosphatase magnesium-dependent 1A is a negative modulator of transforming growth factor β signalling and a potential new therapeutic target in osteoarthritis.
Results indicate that prophylactic use of co-trimoxazole can reduce infection-related mortality in patients with new-onset anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis.
Expression of the Na+-K+-ATPase transmembrane ion transporter is upregulated in kidney-infiltrating B cells in lupus-prone mice and is a potential target for reducing renal B cell survival in patients with lupus nephritis.
A newly developed nanobody that simultaneously targets TNF and IL-6 has greater efficacy than individual targeting in rheumatoid arthritis disease-relevant preclinical models.
Neutrophil extracellular trap proteins trigger an accelerated form of osteoclastogenesis that is enhanced by the presence of carbamylated proteins and is linked to bone erosion.
A panel of serum biomarkers identified by proteomic analysis outperforms the best current alternatives for prediction of the progression of osteoarthritis.
Allogeneic transplantation of cartilage organoids derived from induced pluripotent stem cells promoted cartilage repair in a primate model without eliciting immune reactions.
Autoantibodies against rheumatoid arthritis (RA)-related peptides present in joints can be detected in the serum of patients with early RA using a multiplex immunoassay.
A new study identifies proteinase 3 as an important driver of granuloma formation in granulomatosis with polyangiitis and points to potential therapeutic approaches.
Analyses of data from the Danish national patient register show that diabetes mellitus increases the risk of end-stage renal disease in patients with systemic lupus erythematosus.
