Organisms - Human

  • Cancer genomics

    • Genomics: We are individuals

      Nature Reviews Cancer
      1 November 2009
    • MicroRNA: Stage-specific signatures

      Nature Reviews Cancer
      15 October 2009
    • T (brachyury) gene duplication confers major susceptibility to familial chordoma

      Nature Genetics
      4 October 2009
    • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

      Nature Genetics
      4 October 2009
    • Screening: Chromosomal aberrations in patients with benign, sporadic pheochromocytomas

      Nature Reviews Endocrinology
      1 October 2009
    • Identification of a new prostate cancer susceptibility locus on chromosome 8q24

      Nature Genetics
      20 September 2009
    • Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

      Nature Genetics
      20 September 2009
    • Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

      Nature Genetics
      20 September 2009
    • Multiple loci on 8q24 associated with prostate cancer susceptibility

      Nature Genetics
      20 September 2009
    • Systems genetics analysis of cancer susceptibility: from mouse models to humans

      Nature Reviews Genetics
      28 July 2009
    • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

      Nature
      20 July 2009
    • Breast cancer: Prioritizing targets

      Nature Reviews Cancer
      1 July 2009
    • Genetics: Susceptibility loci in a molecular subtype of prostate cancer

      Nature Reviews Urology
      1 July 2009
    • An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

      Oncogene
      15 June 2009
    • Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification

      Oncogene
      15 June 2009
    • Diagnosis: Novel molecular signatures for adrenocortical carcinoma

      Nature Reviews Endocrinology
      1 June 2009
    • New insights into the aetiology of colorectal cancer from genome-wide association studies

      Nature Reviews Genetics
      1 June 2009
    • Cancer genomics: A modular approach to signalling

      Nature Reviews Genetics
      1 June 2009
    • Beyond odds ratios — communicating disease risk based on genetic profiles

      Nature Reviews Genetics
      1 April 2009
    • HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin

      Nature Chemical Biology
      22 February 2009
    • Dynamic modularity in protein interaction networks predicts breast cancer outcome

      Nature Biotechnology
      1 February 2009
    • p53 polymorphisms: cancer implications

      Nature Reviews Cancer
      1 February 2009
    • Cancer: Identifying drug–genotype interactions

      Nature Reviews Drug Discovery
      1 February 2009
    • Prostate cancer genomics: towards a new understanding

      Nature Reviews Genetics
      1 February 2009
    • Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype

      Nature Reviews Cancer
      16 January 2009
    • Technology: Indirect activation

      Nature Reviews Cancer
      16 January 2009
  • Chemical genomics

    • Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

      Nature Biotechnology
      25 October 2009
    • Synergistic drug combinations tend to improve therapeutically relevant selectivity

      Nature Biotechnology
      5 July 2009
  • Comparative, evolutionary and population genomics

    • Spatial patterns of variation due to natural selection in humans

      Nature Reviews Genetics
      13 October 2009
    • Human genomics: Structural variation catches up

      Nature Reviews Genetics
      13 October 2009
    • Reconstructing Indian population history

      Nature
      24 September 2009
    • Targeted capture and massively parallel sequencing of 12 human exomes

      Nature
      16 August 2009
    • Population genetics: Genetic landscapes out of Africa

      Nature Reviews Genetics
      1 June 2009
    • Human genetic variation and its contribution to complex traits

      Nature Reviews Genetics
      1 April 2009
    • HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin

      Nature Chemical Biology
      22 February 2009
  • Epigenomics

    • Chromatin: Mapping genome-wide chromosome interactions

      Nature Reviews Genetics
      27 October 2009
    • Epigenetics: An expanding horizon for DNA methylation

      Nature Reviews Genetics
      27 October 2009
    • Human epigenomics: Putting epigenetic variation on the map

      Nature Reviews Genetics
      1 October 2009
    • Nutritional programming of the metabolic syndrome

      Nature Reviews Endocrinology
      29 September 2009
    • Chromatin: A peak for exons

      Nature Reviews Genetics
      8 September 2009
    • Sensitive digital quantification of DNA methylation in clinical samples

      Nature Biotechnology
      16 August 2009
    • Insights from genomic profiling of transcription factors

      Nature Reviews Genetics
      11 August 2009
    • From DNA sequence to transcriptional behaviour: a quantitative approach

      Nature Reviews Genetics
      1 July 2009
    • Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

      Nature Reviews Endocrinology
      2 June 2009
    • Gene regulation: A new toolbox for mapping regulatory sites

      Nature Reviews Genetics
      1 May 2009
    • Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

      Nature Biotechnology
      29 March 2009
    • Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

      Nature Biotechnology
      29 March 2009
    • Chromatin: Completing the picture

      Nature Reviews Genetics
      1 March 2009
  • Genetics of Gene Expression

    • Chromatin: Mapping genome-wide chromosome interactions

      Nature Reviews Genetics
      27 October 2009
    • Global patterns of cis variation in human cells revealed by high-density allelic expression analysis

      Nature Genetics
      18 October 2009
    • Obesity: Can genetic susceptibility to obesity be overcome?

      Nature Reviews Endocrinology
      1 October 2009
    • Chromatin: A peak for exons

      Nature Reviews Genetics
      8 September 2009
    • The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism

      Nature Reviews Endocrinology
      25 August 2009
    • Insights from genomic profiling of transcription factors

      Nature Reviews Genetics
      11 August 2009
    • The genetics of quantitative traits: challenges and prospects

      Nature Reviews Genetics
      1 August 2009
    • Genetics of human gene expression: mapping DNA variants that influence gene expression

      Nature Reviews Genetics
      28 July 2009
    • Genetics of gene expression: Putting radiation response on the map

      Nature Reviews Genetics
      1 May 2009
    • Developmental programming of CpG island methylation profiles in the human genome

      Nature Structural & Molecular Biology
      19 April 2009
    • Novel insights into thyroid hormones from the study of common genetic variation

      Nature Reviews Endocrinology
      1 April 2009
  • Genome sequence and analysis

    • Common disorders are quantitative traits

      Nature Reviews Genetics
      27 October 2009
    • A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

      Nature Genetics
      18 October 2009
    • Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

      Nature Genetics
      18 October 2009
    • Human genomics: Structural variation catches up

      Nature Reviews Genetics
      13 October 2009
    • Pharmacogenetics: A SNP for hepatitis C treatment failure

      Nature Reviews Genetics
      13 October 2009
    • Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

      Nature Genetics
      11 October 2009
    • Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

      Nature Genetics
      11 October 2009
    • Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

      Nature Genetics
      11 October 2009
    • A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

      Nature Genetics
      11 October 2009
    • Finding the missing heritability of complex diseases

      Nature
      8 October 2009
    • Human genetics: Hit or miss?

      Nature
      7 October 2009
    • An agenda for personalized medicine

      Nature
      7 October 2009
    • Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

      Nature Genetics
      4 October 2009
    • A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies

      Nature Genetics
      4 October 2009
    • Bayesian statistical methods for genetic association studies

      Nature Reviews Genetics
      1 October 2009
    • Identification of a new prostate cancer susceptibility locus on chromosome 8q24

      Nature Genetics
      20 September 2009
    • Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

      Nature Genetics
      20 September 2009
    • Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

      Nature Genetics
      20 September 2009
    • Multiple loci on 8q24 associated with prostate cancer susceptibility

      Nature Genetics
      20 September 2009
    • Technology: A step closer to personal genomics?

      Nature Reviews Genetics
      15 September 2009
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy

      Nature Genetics
      13 September 2009
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

      Nature Genetics
      13 September 2009
    • Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

      Nature Genetics
      6 September 2009
    • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

      Nature Genetics
      6 September 2009
    • Personalized copy number and segmental duplication maps using next-generation sequencing

      Nature Genetics
      30 August 2009
    • Single-molecule sequencing of an individual human genome

      Nature Biotechnology
      10 August 2009
    • The genetics of quantitative traits: challenges and prospects

      Nature Reviews Genetics
      1 August 2009
    • Complex disease: Schizophrenia: missing heritability found?

      Nature Reviews Genetics
      1 August 2009
    • Technology: The sequencing game

      Nature Reviews Genetics
      1 August 2009
    • Neurogenetics: Schizophrenia: missing heritability found?

      Nature Reviews Neuroscience
      1 August 2009
    • A highly annotated whole-genome sequence of a Korean individual

      Nature
      8 July 2009
    • From DNA sequence to transcriptional behaviour: a quantitative approach

      Nature Reviews Genetics
      1 July 2009
    • The genetic contribution to non-syndromic human obesity

      Nature Reviews Genetics
      1 July 2009
    • An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

      Oncogene
      15 June 2009
    • Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification

      Oncogene
      15 June 2009
    • New insights into the aetiology of colorectal cancer from genome-wide association studies

      Nature Reviews Genetics
      1 June 2009
    • Detecting gene–gene interactions that underlie human diseases

      Nature Reviews Genetics
      1 June 2009
    • Complex disease: Autism clues from genome-wide studies

      Nature Reviews Genetics
      1 June 2009
    • Neurogenetics: Common changes in autism

      Nature Reviews Neuroscience
      1 June 2009
    • Evaluation of C1q genomic region in minority racial groups of lupus

      Genes and Immunity
      14 May 2009
    • Validating, augmenting and refining genome-wide association signals

      Nature Reviews Genetics
      1 May 2009
    • Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies

      Nature Reviews Genetics
      1 May 2009
    • Functional genomics: Structure provides clues

      Nature Reviews Genetics
      1 May 2009
    • Genetics of gene expression: Putting radiation response on the map

      Nature Reviews Genetics
      1 May 2009
    • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

      Nature
      28 April 2009
    • Developmental programming of CpG island methylation profiles in the human genome

      Nature Structural & Molecular Biology
      19 April 2009
    • Beyond odds ratios — communicating disease risk based on genetic profiles

      Nature Reviews Genetics
      1 April 2009
    • New insights into the genetics of addiction

      Nature Reviews Genetics
      1 April 2009
    • Human genetic variation and its contribution to complex traits

      Nature Reviews Genetics
      1 April 2009
    • Personal genomics services: whose genomes?

      European Journal of Human Genetics
      4 March 2009
    • Integrative genomics, personal-genome tests and personalized healthcare: the future is being built today

      European Journal of Human Genetics
      4 March 2009
    • Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing

      Nature Biotechnology
      1 February 2009
    • p53 polymorphisms: cancer implications

      Nature Reviews Cancer
      1 February 2009
    • Alternative splicing: Deciding between the alternatives

      Nature Reviews Genetics
      1 February 2009
    • Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype

      Nature Reviews Cancer
      16 January 2009
    • Direct-to-consumer genome scanning services. Also for children?

      Nature Reviews Genetics
      1 January 2009
    • Human disease: Genome-wide insights into lipid levels

      Nature Reviews Genetics
      1 January 2009
  • Metabolomics/nomics

    • Diabetes: GATTACA—are we there yet?

      Nature Reviews Endocrinology
      1 April 2009
    • Proteomic and metabolic prediction of response to therapy in gastrointestinal cancers

      Nature Clinical Practice Gastroenterology & Hepatology
      1 March 2009
    • Human disease: Genome-wide insights into lipid levels

      Nature Reviews Genetics
      1 January 2009
  • Pharmacogenomics

    • Pharmacogenetics: A SNP for hepatitis C treatment failure

      Nature Reviews Genetics
      13 October 2009
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy

      Nature Genetics
      13 September 2009
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

      Nature Genetics
      13 September 2009
    • Pharmacogenetics: Optimizing warfarin therapy

      Nature Reviews Cardiology
      1 May 2009
    • Universal sample preparation method for proteome analysis

      Nature Methods
      19 April 2009
    • A network view of disease and compound screening

      Nature Reviews Drug Discovery
      1 April 2009
    • Cancer: Identifying drug–genotype interactions

      Nature Reviews Drug Discovery
      1 February 2009
    • Pharmacogenomic progress in individualized dosing of key drugs for cancer patients

      Nature Clinical Practice Oncology
      27 January 2009
  • Proteomics

    • One system to express them all

      PSI Structural Genomics Knowledgebase
      14 October 2009
    • Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

      Nature Biotechnology
      4 October 2009
    • Neuroproteomics: understanding the molecular organization and complexity of the brain

      Nature Reviews Neuroscience
      1 September 2009
    • Post-translational modification: The DUB interaction landscape

      Nature Reviews Molecular Cell Biology
      1 August 2009
    • Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

      Nature Biotechnology
      28 June 2009
    • p53 and little brother p53/47: linking IRES activities with protein functions

      Oncogene
      1 June 2009
    • Proteomics: Biomarkers on a nanoscale

      Nature Reviews Cancer
      30 April 2009
    • Proteomic and metabolic prediction of response to therapy in gastrointestinal cancers

      Nature Clinical Practice Gastroenterology & Hepatology
      1 March 2009
    • Chromatin: Completing the picture

      Nature Reviews Genetics
      1 March 2009
    • Proteasome Subunits mRNA Expressions Correlate With Male BMI: Implications for a Role in Obesity

      Obesity
      22 January 2009
  • Systems biology

    • Neuroproteomics: understanding the molecular organization and complexity of the brain

      Nature Reviews Neuroscience
      1 September 2009
    • The genetics of quantitative traits: challenges and prospects

      Nature Reviews Genetics
      1 August 2009
    • Systems genetics analysis of cancer susceptibility: from mouse models to humans

      Nature Reviews Genetics
      28 July 2009
    • Cancer genomics: A modular approach to signalling

      Nature Reviews Genetics
      1 June 2009
    • A network view of disease and compound screening

      Nature Reviews Drug Discovery
      1 April 2009
  • Techniques and methods

    • Common disorders are quantitative traits

      Nature Reviews Genetics
      27 October 2009
    • Chromatin: Mapping genome-wide chromosome interactions

      Nature Reviews Genetics
      27 October 2009
    • Epigenetics: An expanding horizon for DNA methylation

      Nature Reviews Genetics
      27 October 2009
    • One system to express them all

      PSI Structural Genomics Knowledgebase
      14 October 2009
    • Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

      Nature Biotechnology
      4 October 2009
    • Bayesian statistical methods for genetic association studies

      Nature Reviews Genetics
      1 October 2009
    • Disease signatures are robust across tissues and experiments

      Molecular Systems Biology
      15 September 2009
    • Technology: A step closer to personal genomics?

      Nature Reviews Genetics
      15 September 2009
    • Technology: The sequencing game

      Nature Reviews Genetics
      1 August 2009
    • Genetics of human gene expression: mapping DNA variants that influence gene expression

      Nature Reviews Genetics
      28 July 2009
    • Monitoring peptidase activities in complex proteomes by MALDI-TOF mass spectrometry

      Nature Protocols
      23 July 2009
    • From DNA sequence to transcriptional behaviour: a quantitative approach

      Nature Reviews Genetics
      1 July 2009
    • Transcriptomics: Revealing the extent of RNA editing

      Nature Reviews Genetics
      1 July 2009
    • Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins

      Nature Biotechnology
      28 June 2009
    • Detecting gene–gene interactions that underlie human diseases

      Nature Reviews Genetics
      1 June 2009
    • Cancer genomics: A modular approach to signalling

      Nature Reviews Genetics
      1 June 2009
    • Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing

      Nature Protocols
      28 May 2009
    • Construction and flow cytometric screening of targeted enzyme libraries

      Nature Protocols
      21 May 2009
    • A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS)

      Nature Protocols
      14 May 2009
    • Validating, augmenting and refining genome-wide association signals

      Nature Reviews Genetics
      1 May 2009
    • Data sharing in genomics — re-shaping scientific practice

      Nature Reviews Genetics
      1 May 2009
    • Gene regulation: A new toolbox for mapping regulatory sites

      Nature Reviews Genetics
      1 May 2009
    • Proteomics: Biomarkers on a nanoscale

      Nature Reviews Cancer
      30 April 2009
    • Universal sample preparation method for proteome analysis

      Nature Methods
      19 April 2009
    • A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics

      Nature Protocols
      16 April 2009
    • Chromatin: Completing the picture

      Nature Reviews Genetics
      1 March 2009
    • Construction of Parallel Analysis of RNA Ends (PARE) libraries for the study of cleaved miRNA targets and the RNA degradome

      Nature Protocols
      26 February 2009
    • Dynamic modularity in protein interaction networks predicts breast cancer outcome

      Nature Biotechnology
      1 February 2009
    • Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing

      Nature Biotechnology
      1 February 2009
    • Technology: Indirect activation

      Nature Reviews Cancer
      16 January 2009
    • PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls

      Nature Biotechnology
      4 January 2009
    • RNA-Seq: a revolutionary tool for transcriptomics

      Nature Reviews Genetics
      1 January 2009
  • Transcriptomics

    • Genomics: We are individuals

      Nature Reviews Cancer
      1 November 2009
    • MicroRNA: Stage-specific signatures

      Nature Reviews Cancer
      15 October 2009
    • Disease signatures are robust across tissues and experiments

      Molecular Systems Biology
      15 September 2009
    • Insights from genomic profiling of transcription factors

      Nature Reviews Genetics
      11 August 2009
    • The genetics of quantitative traits: challenges and prospects

      Nature Reviews Genetics
      1 August 2009
    • Genetics of human gene expression: mapping DNA variants that influence gene expression

      Nature Reviews Genetics
      28 July 2009
    • Transcriptomics: Revealing the extent of RNA editing

      Nature Reviews Genetics
      1 July 2009
    • An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

      Oncogene
      15 June 2009
    • Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification

      Oncogene
      15 June 2009
    • p53 and little brother p53/47: linking IRES activities with protein functions

      Oncogene
      1 June 2009
    • Alternative splicing: Deciding between the alternatives

      Nature Reviews Genetics
      1 February 2009
    • RNA-Seq: a revolutionary tool for transcriptomics

      Nature Reviews Genetics
      1 January 2009

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