Welcome to RNAi Gateway
From humble beginnings as an obscure phenomenon in plants, RNA interference (RNAi) has evolved into an area of significant impact in numerous fields. This RNAi Gateway provides a convenient portal into publications relevant to every aspect of RNAi from journals throughout the Nature Publishing Group.
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Latest Highlight
Controlling the embryonic stem cell cycle FREE
Nature Genetics
2 November 2008
Dgcr8-knockout embryonic stem (ES) cells lack microprocessor activity and therefore all canonical microRNAs (miRNAs), and exhibit cell proliferation defects. By screening individual miRNAs from a comprehensive library in these knockout cells, Robert Blelloch and colleagues identify ES-cell-specific miRNAs that accelerate the G1—S transition of the ES cell cycle and promote proliferation. By examining the effects of expressing individual miRNAs in cells that lack endogenous miRNAs, they overcame the issues of redundancy and saturation that are inherent to the miRNA system. This approach therefore provides an alternative and powerful strategy for evaluating the numerous functions of miRNAs in a wide array of biological processes.
Current Content
Find out what's new in RNAi by browsing research reports, reviews, news and comment — all conveniently collected here from Nature Publishing Group's wide range of journals. To select the very latest developments by category, click on any of the links below.
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Podcast
30 October 2008
Tune in to find out more about the expanding world of small RNAs. Get the low-down on where we find them, what we know (and don't know) about what they do and even how they evolved.
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