Featured
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Article
| Open AccessMiR-21-5p modulates LPS-induced acute injury in alveolar epithelial cells by targeting SLC16A10
- Huanan Zeng
- , Yuqing Zhou
- & Wei Liu
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Article
| Open AccessCBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway
- Zhimin Dou
- , Fei Lu
- & Xun Li
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Article
| Open AccessTASL mediates keratinocyte differentiation by regulating intracellular calcium levels and lysosomal function
- Ji Yeong Park
- , Hyeng-Soo Kim
- & Zae Young Ryoo
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Article
| Open AccessPhotobiomodulation on isolated mitochondria at 810 nm: first results on the efficiency of the energy conversion process
- Andrea Amaroli
- , Mario Rene Clemente Vargas
- & Silvia Ravera
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Article
| Open AccessEstablishment, characterization, and genetic profiling of patient-derived osteosarcoma cells from a patient with retinoblastoma
- Patcharawadee Thongkumkoon
- , Apiwat Sangphukieo
- & Parunya Chaiyawat
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Article
| Open AccessHypertonic saline- and detergent-accelerated EDTA-based decalcification better preserves mRNA of bones
- Zhongmin Li
- , Clara Wenhart
- & Goetz Muench
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Article
| Open AccessA dual model of normal vs isogenic Nrf2-depleted murine epithelial cells to explore oxidative stress involvement
- Jacques Dupuy
- , Edwin Fouché
- & Cécile Héliès-Toussaint
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Article
| Open AccessIntegrated single-cell and bulk RNA-Seq analysis enhances prognostic accuracy of PD-1/PD-L1 immunotherapy response in lung adenocarcinoma through necroptotic anoikis gene signatures
- Ping Sui
- , Xueping Liu
- & Zhanming Sha
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Article
| Open AccessEugenol as a potential adjuvant therapy for gingival squamous cell carcinoma
- Hawraa Issa
- , Lionel Loubaki
- & Abdelhabib Semlali
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Article
| Open AccessExploring the mystery of colon cancer from the perspective of molecular subtypes and treatment
- Wenhong Lu
- , Qiwei Wang
- & Wenpeng Luo
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Article
| Open AccessTwist2 contributes to skin regeneration and hair follicle formation in mouse fetuses
- Kento Takaya
- , Ayano Sunohara
- & Kazuo Kishi
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Article
| Open AccessFirst in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY
- Hannah C. Wanstall
- , Florian Burkart
- & Roger M. Jones
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Article
| Open AccessAstroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model
- Ezgi Ozdemir Takase
- , Ryo Yamasaki
- & Noriko Isobe
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Article
| Open AccessTranscriptomic analysis of the effect of remote ischaemic conditioning in an animal model of necrotising enterocolitis
- Ian Howard Jones
- , Jane Elizabeth Collins
- & Ashley Ivan Heinson
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Article
| Open AccessInflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1
- Shujiang Zhuo
- , Sufei Song
- & Kaili Chen
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Article
| Open AccessAngiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes
- Yukimasa Takeda
- , Toshikazu Yoshikawa
- & Ping Dai
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Article
| Open AccessAntiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2
- Tiago Nicoliche
- , Cynthia Silva Bartolomeo
- & Roberta Sessa Stilhano
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Article
| Open AccessChaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- Donghyeon Yeo
- , Yeo Gyun Yun
- & Hae-Won Kim
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Article
| Open AccessO-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats
- Thomas Dupas
- , Amandine Vergnaud
- & Benjamin Lauzier
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Article
| Open AccessGenerating an organ-deficient animal model using a multi-targeted CRISPR-Cas9 system
- Jonathan Jun-Yong Lim
- , Yamato Murata
- & Ayako Isotani
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Article
| Open AccessLRBA, a BEACH protein mutated in human immune deficiency, is widely expressed in epithelia, exocrine and endocrine glands, and neurons
- Eleni Roussa
- , Pavel Juda
- & Manfred W. Kilimann
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Article
| Open AccessThe prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma
- Zhongkai Wu
- , Lilong Zhang
- & Weixing Wang
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Article
| Open AccessCetuximab inhibits colorectal cancer development through inactivating the Wnt/β-catenin pathway and modulating PLCB3 expression
- Xiaohong Zhang
- , Wenming Zhou
- & Xingxing Zhang
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Article
| Open AccessThe stress-responsive cytotoxic effect of diesel exhaust particles on lymphatic endothelial cells
- Yu Sakurai
- , Eiki Oba
- & Hidetaka Akita
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Article
| Open AccessYANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway
- Yue Shi
- , Yue Cheng
- & Qiuhong Duan
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Article
| Open AccessSynchronous profiling of mRNA N6-methyladenosine modifications and mRNA expression in high-grade serous ovarian cancer: a pilot study
- Li Yang
- , Jingfang Liu
- & Aijun Yu
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Article
| Open AccessAggregation of human osteoblasts unlocks self-reliant differentiation and constitutes a microenvironment for 3D-co-cultivation with other bone marrow cells
- Sabrina Marozin
- , Birgit Simon-Nobbe
- & Günter Lepperdinger
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Article
| Open AccessThe local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics
- Nicoletta Braidotti
- , Giorgia Demontis
- & Dan Cojoc
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Article
| Open AccessThe interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner
- Wannapa Sornjai
- , Ploenphit Promma
- & Duncan R. Smith
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Article
| Open AccessA Japanese herbal medicine (kampo), hochuekkito (TJ-41), has anti-inflammatory effects on the chronic obstructive pulmonary disease mouse model
- Masaaki Yuki
- , Taro Ishimori
- & Akihisa Mitani
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Article
| Open AccessHigh histone crotonylation modification in bovine fibroblasts promotes cell proliferation and the developmental efficiency of preimplantation nuclear transfer embryos
- Xiaoyu Zhao
- , Mengxin Du
- & Guangpeng Li
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Article
| Open AccessBiosynthesized BiFe2O4@Ag nanoparticles mediated Scenedesmus obliquus induce apoptosis in AGS gastric cancer cell line
- Hossein Shamsi
- , Reza Yari
- & Ali Salehzadeh
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Article
| Open AccessSDPR expression in human trabecular meshwork and its potential role in racial disparities of glaucoma
- Ying-Bo Shui
- , Ying Liu
- & Carla J. Siegfried
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Article
| Open AccessTranscription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy
- Judy Yan
- , Shanti Mehta
- & Stephan Ong Tone
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Article
| Open AccessMesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction
- So Kurawaki
- , Ayumu Nakashima
- & Takao Masaki
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Article
| Open AccessStorage conditions affect the composition of the lyophilized secretome of multipotent mesenchymal stromal cells
- Olena Rogulska
- , Irena Vackova
- & Yuriy Petrenko
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Article
| Open AccessThe amoeboid migration of monocytes in confining channels requires the local remodeling of the cortical actin cytoskeleton by cofilin-1
- Maria F. Ullo
- , Anna E. D’Amico
- & Jeremy S. Logue
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Article
| Open AccessFollicle-stimulating hormone receptor expression in advanced atherosclerotic plaques
- Nicolae Ghinea
- , Elisa Anamaria Liehn
- & Tine Kold Olesen
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Article
| Open AccessCOPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation
- Frédéric Anglès
- , Vijay Gupta
- & William E. Balch
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Article
| Open AccessCORVET-specific subunit levels determine the balance between HOPS/CORVET endosomal tethering complexes
- Ármin Sőth
- , Márton Molnár
- & Gábor Juhász
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Article
| Open AccessOn the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation
- Xixi Wang
- , Yanfei Wang
- & Yalian Sa
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Editorial
| Open AccessMitochondrial dynamics: updates and perspectives
Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.
- Kezhong Zhang
- & Ježek Petr
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Article
| Open AccessA high efficiency precision genome editing method with CRISPR in iPSCs
- Avinash Singh
- , G. Dalton Smedley
- & Shauna H. Yuan
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Article
| Open AccessA minimal Fanconi Anemia complex in early diverging fungi
- Drishtee Barua
- , Magdalena Płecha
- & Anna Muszewska
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Article
| Open AccessPolyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
- Nina Kunová
- , Gabriela Ondrovičová
- & Vladimír Pevala
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Article
| Open AccessSaturated fatty acids inhibit unsaturated fatty acid induced glucose uptake involving GLUT10 and aerobic glycolysis in bovine granulosa cells
- Xuelian Tao
- , Maryam Rahimi
- & Vijay Simha Baddela
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Article
| Open AccessComparing the efficacy of concomitant treatment of resistance exercise and creatine monohydrate versus multiple individual therapies in age related sarcopenia
- Eman I. Elgizawy
- , Ghada S. Amer
- & Anwar M. Shaban
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Article
| Open AccessMechanical stimulation of induced pluripotent stem derived cardiac fibroblasts
- Fjodor T. Bekedam
- , Rowan Smal
- & Aida Llucià-Valldeperas
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Article
| Open AccessGross morphology and adhesion-associated physical properties of Drosophila larval salivary gland glue secretion
- Milan Beňo
- , Denisa Beňová-Liszeková
- & Robert Farkaš
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