Featured
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Article |
Accurate structure prediction of biomolecular interactions with AlphaFold 3
- Josh Abramson
- , Jonas Adler
- & John M. Jumper
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Research Briefing |
‘Ghost roads’ could be the biggest direct threat to tropical forests
By using volunteers to map roads in forests across Borneo, Sumatra and New Guinea, an innovative study shows that existing maps of the Asia-Pacific region are rife with errors. It also reveals that unmapped roads are extremely common — up to seven times more abundant than mapped ones. Such ‘ghost roads’ are promoting illegal logging, mining, wildlife poaching and deforestation in some of the world’s biologically richest ecosystems.
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News |
Major AlphaFold upgrade offers boost for drug discovery
Latest version of the AI models how proteins interact with other molecules — but DeepMind restricts access to the tool.
- Ewen Callaway
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Article
| Open AccessThe intrinsic substrate specificity of the human tyrosine kinome
An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.
- Tomer M. Yaron-Barir
- , Brian A. Joughin
- & Jared L. Johnson
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Article
| Open AccessComputationally restoring the potency of a clinical antibody against Omicron
By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.
- Thomas A. Desautels
- , Kathryn T. Arrildt
- & Daniel M. Faissol
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News |
Who’s making chips for AI? Chinese manufacturers lag behind US tech giants
Researchers in China say they are finding themselves five to ten years behind their US counterparts as export restrictions bite.
- Jonathan O'Callaghan
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News |
‘ChatGPT for CRISPR’ creates new gene-editing tools
Some of the AI-designed gene editors could be more versatile than those found in nature.
- Ewen Callaway
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Technology Feature |
85 million cells — and counting — at your fingertips
Chan Zuckerberg CELL by GENE Discover aims to be a one-stop shop for single-cell RNA sequencing data storage, access and analysis.
- Jeffrey M. Perkel
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News Feature |
Lethal AI weapons are here: how can we control them?
Autonomous weapons guided by artificial intelligence are already in use. Researchers, legal experts and ethicists are struggling with what should be allowed on the battlefield.
- David Adam
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Comment |
Will AI accelerate or delay the race to net-zero emissions?
As artificial intelligence transforms the global economy, researchers need to explore scenarios to assess how it can help, rather than harm, the climate.
- Amy Luers
- , Jonathan Koomey
- & Eric Horvitz
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Outlook |
AI’s keen diagnostic eye
Powered by deep-learning algorithms, artificial intelligence systems could replace agents such as chemicals currently used to augment medical scans.
- Neil Savage
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Nature Video |
AI and robotics demystify the workings of a fly's wing
New research unveils the workings of one of the most complex bio-mechanical structures in the natural world
- Dan Fox
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News |
AI traces mysterious metastatic cancers to their source
Algorithm examines images of metastatic cells to identify the location of the primary tumour.
- Smriti Mallapaty
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News |
AI now beats humans at basic tasks — new benchmarks are needed, says major report
Stanford University’s 2024 AI Index charts the meteoric rise of artificial-intelligence tools.
- Nicola Jones
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News |
Is ChatGPT corrupting peer review? Telltale words hint at AI use
A study of review reports identifies dozens of adjectives that could indicate text written with the help of chatbots.
- Dalmeet Singh Chawla
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Article
| Open AccessEmergence of fractal geometries in the evolution of a metabolic enzyme
Citrate synthase from the cyanobacterium Synechococcus elongatus is shown to self-assemble into Sierpiński triangles, a finding that opens up the possibility that other naturally occurring molecular-scale fractals exist.
- Franziska L. Sendker
- , Yat Kei Lo
- & Georg K. A. Hochberg
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Correspondence |
How to break big tech’s stranglehold on AI in academia
- Michał Woźniak
- & Paweł Ksieniewicz
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Comment |
AI can help to tailor drugs for Africa — but Africans should lead the way
Computational models that require very little data could transform biomedical and drug development research in Africa, as long as infrastructure, trained staff and secure databases are available.
- Gemma Turon
- , Mathew Njoroge
- & Kelly Chibale
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Technology Feature |
‘Without these tools, I’d be lost’: how generative AI aids in accessibility
A rush to place barriers around the use of artificial intelligence in academia could disproportionately affect those who stand to benefit most.
- Amanda Heidt
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Career Column |
Three ways ChatGPT helps me in my academic writing
Generative AI can be a valuable aid in writing, editing and peer review – if you use it responsibly, says Dritjon Gruda.
- Dritjon Gruda
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Career Feature |
Ready or not, AI is coming to science education — and students have opinions
As educators debate whether it’s even possible to use AI safely in research and education, students are taking a role in shaping its responsible use.
- Sarah Wells
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Research Briefing |
Artificial intelligence can provide accurate forecasts of extreme floods at global scale
Anthropogenic climate change is accelerating the hydrological cycle, causing an increase in the risk of flood-related disasters. A system that uses artificial intelligence allows the creation of reliable, global river flood forecasts, even in places where accurate local data are not available.
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Article
| Open AccessImmune microniches shape intestinal Treg function
Studies in mice show that effector T regulatory cells in the gut are most functional in the lamina propria, but this homeostatic niche is disrupted in inflammation, suggesting a spatial mechanism of tolerance to commensal microorganisms.
- Yisu Gu
- , Raquel Bartolomé-Casado
- & Fiona Powrie
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Article
| Open AccessThe complex polyploid genome architecture of sugarcane
We build a polyploid reference genome for hybrid sugarcane cultivar R570, improving on its current ‘mosaic monoploid’ representation, enabling fine-grain description of genome architecture and the exploration of candidate genes underlying the Bru1 brown rust resistance locus.
- A. L. Healey
- , O. Garsmeur
- & A. D’Hont
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Article
| Open AccessSingle-cell multiplex chromatin and RNA interactions in ageing human brain
We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.
- Xingzhao Wen
- , Zhifei Luo
- & Sheng Zhong
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News Feature |
How AI is improving climate forecasts
Researchers are using various machine-learning strategies to speed up climate modelling, reduce its energy costs and hopefully improve accuracy.
- Carissa Wong
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News |
Google AI could soon use a person’s cough to diagnose disease
Machine-learning system trained on millions of human audio clips shows promise for detecting COVID-19 and tuberculosis.
- Mariana Lenharo
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Article
| Open AccessA distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche
A study reveals that Fusobacterium nucleatum subspecies animalis is bifurcated into two distinct clades, and shows that only one of these dominates the colorectal cancer niche, probably through increased colonization of the human gastrointestinal tract.
- Martha Zepeda-Rivera
- , Samuel S. Minot
- & Christopher D. Johnston
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Correspondence |
Three reasons why AI doesn’t model human language
- Johan J. Bolhuis
- , Stephen Crain
- & Andrea Moro
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News |
‘A landmark moment’: scientists use AI to design antibodies from scratch
Modified protein-design tool could make it easier to tackle challenging drug targets — but AI antibodies are still a long way from reaching the clinic.
- Ewen Callaway
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News Feature |
AI image generators often give racist and sexist results: can they be fixed?
Researchers are tracing sources of racial and gender bias in images generated by artificial intelligence, and making efforts to fix them.
- Ananya
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News & Views |
Can lessons from infants solve the problems of data-greedy AI?
Words and images experienced by an infant wearing sensors during their daily life have led to efficient machine learning, pointing to the power of multimodal training signals and to the potentially exploitable statistics of real-life experience.
- Linda B. Smith
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Research Briefing |
‘Bandit’ algorithms help chemists to discover generally applicable conditions for reactions
In organic chemistry, finding conditions that enable a broad range of compounds to undergo a particular type of reaction is highly desirable. However, conventional methods for doing so consume a lot of time and reagents. A machine-learning method has been developed that overcomes these problems.
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Nature Index |
How AI is being used to accelerate clinical trials
From study design to patient recruitment, researchers are investigating ways that technology could speed up the process.
- Matthew Hutson
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Nature Index |
Four change-makers seek impact in medical research
Bringing fresh perspectives to long-standing health challenges, these scientists are using techniques such as big-data analytics and AI to push the field.
- Amy Coombs
- & Sandy Ong
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News |
Chatbot AI makes racist judgements on the basis of dialect
Some large language models harbour hidden biases that cannot be removed using standard methods.
- Elizabeth Gibney
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Article
| Open AccessBlueprinting extendable nanomaterials with standardized protein blocks
A study describes an approach using designed building blocks that are far more regular in geometry than natural proteins to construct modular multicomponent protein assemblies.
- Timothy F. Huddy
- , Yang Hsia
- & David Baker
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Article
| Open AccessSpatially organized cellular communities form the developing human heart
Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of cardiac cell types that form and remodel the human heart.
- Elie N. Farah
- , Robert K. Hu
- & Neil C. Chi
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Correspondence |
Embrace AI to break down barriers in publishing for people who aren’t fluent in English
- Charles Morphy D. Santos
- & João Paulo Gois
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Technology Feature |
No installation required: how WebAssembly is changing scientific computing
Enabling code execution in the web browser, the multilanguage tool is powerful but complicated.
- Jeffrey M. Perkel
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News |
Could AI-designed proteins be weaponized? Scientists lay out safety guidelines
AI tools that can come up with protein structures at the push of a button should be used safely and ethically, say researchers in the field.
- Ewen Callaway
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News Explainer |
AI-generated images and video are here: how could they shape research?
Scientists are already using image-generating models to jazz up papers and presentations. But some say these tools could harm research.
- Carissa Wong
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Editorial |
Why scientists trust AI too much — and what to do about it
Some researchers see superhuman qualities in artificial intelligence. All scientists need to be alert to the risks this creates.
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Article
| Open AccessDecoding chromatin states by proteomic profiling of nucleosome readers
A multidimensional proteomics analysis of the interactions between around 2,000 nuclear proteins and over 80 modified dinucleosomes representing promoter, enhancer and heterochromatin states provides insights into how chromatin states are decoded by chromatin readers.
- Saulius Lukauskas
- , Andrey Tvardovskiy
- & Till Bartke
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World View |
Here’s what many digital tools for chronic pain are doing wrong
To address the chronic-pain crisis, digital health technologies must break out of their silos and become integrative and holistic.
- Benjamin Lipp
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News Explainer |
Is ChatGPT making scientists hyper-productive? The highs and lows of using AI
Large language models are transforming scientific writing and publishing. But the productivity boost that these tools bring could have a downside.
- McKenzie Prillaman
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Article
| Open AccessAutomated model building and protein identification in cryo-EM maps
ModelAngelo builds atomic models and identifies proteins with unknown sequences in cryo-EM maps.
- Kiarash Jamali
- , Lukas Käll
- & Sjors H. W. Scheres
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Article
| Open AccessPrevalence of persistent SARS-CoV-2 in a large community surveillance study
Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.
- Mahan Ghafari
- , Matthew Hall
- & Katrina Lythgoe
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Correspondence |
Stockholm declaration on AI ethics: why others should sign
- Ross D. King
- , Teresa Scassa
- & Hiroaki Kitano
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